All Phenotypes Cdc25a<tm1Kiyo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdc25a^tm1Kiyo
targeted mutation 1, Hiroaki Kiyokawa
MGI:3717591

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc25a^tm1Kiyo/Cdc25a^tm1Kiyo	involves: 129/Sv * C57BL/6	MGI:3718001
cx2	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-vHaras)SH1Led/?	involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1	MGI:3718002
cx3	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-Myc)141-3Led/?	involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1	MGI:3718004
cx4	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-Erbb2)NK1Mul/?	involves: 129/Sv * C57BL/6 * FVB/N	MGI:3718003

Allelic Composition	Cdc25a^tm1Kiyo/Cdc25a^tm1Kiyo
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1Kiyo mutation (0 available); any Cdc25a mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:123144 )

• mice die between E5 and E7

embryo

abnormal blastocyst hatching ( J:123144 )

• E3.5 embryos display impaired hatching when cultured

Allelic Composition	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-vHaras)SH1Led/?
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1Kiyo mutation (0 available); any Cdc25a mutation (34 available)
Tg(MMTV-vHaras)SH1Led mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of induced tumors ( J:123144 )

• mice develop mammary and salivary tumors with a latency of 60 weeks compared to 18 weeks in Tg(MMTV-vHaras)SH1Led transgenic mice

• 10% of mice do not develop tumors within 2 years of observation

Allelic Composition	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-Myc)141-3Led/?
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1Kiyo mutation (0 available); any Cdc25a mutation (34 available)
Tg(MMTV-Myc)141-3Led mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:123144 )

N	• tumorigenesis is similar to in Tg(MMTV-Myc)141-3Led transgenic mice

Allelic Composition	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-Erbb2)NK1Mul/?
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1Kiyo mutation (0 available); any Cdc25a mutation (34 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of induced tumors ( J:123144 )

• mice develop tumors at a latency of 32 weeks compared to 23 weeks in Tg(MMTV-Erbb2)NK1Mul transgenic mice

• mice do not develop hyperplastic nodules in mammary glands as do Tg(MMTV-Erbb2)NK1Mul transgenic mice

cellular

decreased cell proliferation ( J:123144 )

• fewer cells are in S-phase and proliferation is decreased compared to in Tg(MMTV-Erbb2)NK1Mul transgenic mice

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