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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga2btm1Graf
targeted mutation 1, Thomas Graf
MGI:3717592
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itga2btm1Graf/Itga2btm1Graf B6.Cg-Itga2btm1Graf MGI:3717892
ht2
 		Itga2btm1Graf/Itga2b+ B6.Cg-Itga2btm1Graf MGI:3717891
cx3
 		Itga2btm1Graf/Itga2btm1Graf
Tfpitm1Gjb/Tfpitm1Gjb 		involves: 129 * C57BL/6J * SJL MGI:6423683


Genotype
MGI:3717892
hm1
Allelic
Composition		 Itga2btm1Graf/Itga2btm1Graf
Genetic
Background		 B6.Cg-Itga2btm1Graf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2btm1Graf mutation (0 available); any Itga2b mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:123159 )
N
• mice are fertile




Genotype
MGI:3717891
ht2
Allelic
Composition		 Itga2btm1Graf/Itga2b+
Genetic
Background		 B6.Cg-Itga2btm1Graf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2btm1Graf mutation (0 available); any Itga2b mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thrombocytopenia ( J:123159 )
• following whole body irradiation, the numbe rof YFP+ platelets decreases by 2-fold after day 6 of exposure
abnormal platelet activation ( J:123159 )
• YFP+ platelets are more responsive to thrombin stimulation than YFP- platelets within the same mouse

homeostasis/metabolism
abnormal platelet activation ( J:123159 )
• YFP+ platelets are more responsive to thrombin stimulation than YFP- platelets within the same mouse




Genotype
MGI:6423683
cx3
Allelic
Composition		 Itga2btm1Graf/Itga2btm1Graf
Tfpitm1Gjb/Tfpitm1Gjb
Genetic
Background		 involves: 129 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2btm1Graf mutation (0 available); any Itga2b mutation (45 available)
Tfpitm1Gjb mutation (0 available); any Tfpi mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:283423 )
• 3 of 6 mice die by 4 weeks of age
preweaning lethality, incomplete penetrance ( J:283423 )
• incomplete rescue of pre-weaning lethality

nervous system
hydrocephaly ( J:283423 )
• in mice that die by 4 weeks of age
enlarged brain ventricles ( J:283423 )
• compared with mice heterozygous for a Tfpi null allele

skeleton
domed cranium ( J:283423 )
• in mice that die by 4 weeks of age

craniofacial
domed cranium ( J:283423 )
• in mice that die by 4 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory