Phenotypes associated with this allele

• Allele Symbol: Tg(Eno2-PTGS2)32Pasi
• Allele Name: transgene insertion 32, Guilio Maria Pasinetti
• Allele ID: MGI:3717604
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(APP695)3Dbo/0 Tg(Eno2-PTGS2)32Pasi/0 Tg(PSEN1)5Dbo/0	involves: C3H/HeJ * C57BL/6J	MGI:3720017
tg2	Tg(Eno2-PTGS2)32Pasi/0	involves: C3H/HeNTac * C57BL/6NTac	MGI:3717606

Genotype
MGI:3720017

cx1

• Allelic Composition: Tg(APP695)3Dbo/0; Tg(Eno2-PTGS2)32Pasi/0; Tg(PSEN1)5Dbo/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:100961 )

N • no differences in neuron number in cingulate cortex relative to wild-type

amyloid beta deposits ( J:100961 )

• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation

homeostasis/metabolism

amyloid beta deposits ( J:100961 )

• immunoreactive amyloid beta deposits are observed in the cingulate cortex in 12 month-old triple transgenic mice; deposits are most evident in gray matter of cingulare and enthorhinal cortex, and to lesser extent in non-neuronal layers of the hippocampal formation

Genotype
MGI:3717606

tg2

• Allelic Composition: Tg(Eno2-PTGS2)32Pasi/0
• Genetic Background: involves: C3H/HeNTac * C57BL/6NTac

mortality/aging

premature death ( J:100973 )

• within 10 minutes of kainic acid infusion, vigorous status epilepticus leads to death in transgenic animals whereas no wild-type mice die after kainic acid treatment

behavior/neurological

seizures ( J:100973 )

• intensity of kainic acid-induced seizures is elevated in transgenic mice relative to wild-type

tonic-clonic seizures ( J:100973 )

• severe seizures in kainic acid-treated mice are associated with generalized tonic-clonic seizures with wild seizure jumps, while wild-type mice do not show any myoclonic twitches

nervous system

nervous system phenotype ( J:100961 )

N • no amyloid beta deposits are observed in transgenic mouse brains

N • no differences in neuron number in cingulate cortex relative to wild-type

seizures ( J:100973 )

• intensity of kainic acid-induced seizures is elevated in transgenic mice relative to wild-type

tonic-clonic seizures ( J:100973 )

• severe seizures in kainic acid-treated mice are associated with generalized tonic-clonic seizures with wild seizure jumps, while wild-type mice do not show any myoclonic twitches

abnormal neuron physiology ( J:100961 )

• PTGS2 overexpression in neurons potentiates amyloid beta-mediated neuronal apoptotic damage in cortico-hippocampal cultures

increased susceptibility to neuronal excitotoxicity ( J:100973 )

• in cultured cortico-hippocampal neurons, exposure to glutamate results in 46% impairment of redox activity compared to 31.2% in control neurons, indicating potentiation of excitotoxicity in vitro

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:100973 )

• in cultured cortico-hippocampal neurons, exposure to glutamate results in 46% impairment of redox activity compared to 31.2% in control neurons, indicating potentiation of excitotoxicity in vitro

cellular

increased susceptibility to neuronal excitotoxicity ( J:100973 )

• in cultured cortico-hippocampal neurons, exposure to glutamate results in 46% impairment of redox activity compared to 31.2% in control neurons, indicating potentiation of excitotoxicity in vitro