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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptpn6m1Btlr
mutation 1, Bruce Beutler
MGI:3717648
Summary 5 genotypes


Genotype
MGI:3717649
hm1
Allelic
Composition		 Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic
Background		 C57BL/6J-Ptpn6m1Btlr/Mmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Chronic inflammation in Ptpn6m1Btlr/Ptpn6m1Btlr mice

mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:142845 )
• inoculation with 5x105 CFUs leads to the death of all controls while killing none of the mutant mice

limbs/digits/tail
ulcerated autopod ( J:142845 )
• plantar surfaces of the feet develop inflamed, raw, weeping lesions in 90% of mice between 10 and 25 weeks of age
• this inflammation leads to thickening of the epidermis, microabscesses in the epidermal and dermal layers, and a neutrophilic infiltrate in the dermal layer
• cellularity of the bone marrow adjacent to lesions is increased
• this phenotype is dependent on the presence of microbes in the housing

immune system
enlarged spleen ( J:94077 , J:142845 )
• splenomegaly (J:94077)
• occurs in mice after 6 weeks of age with a mean weight of 98 mg compared to 68 mg (J:142845)
• this phenotype is dependent on the presence of microbes in the housing (J:142845)
decreased mature B cell number ( J:142845 )
• there is a 40%-50% reduction in the number of mature B cells in the peripheral blood and bone marrow
abnormal myeloid leukocyte morphology ( J:142845 )
• there are an increased number of myeloid cells in the spleen and bone marrow of mice over 7 weeks of age
increased neutrophil cell number ( J:142845 )
• increased numbers of neutrophils are found in the spleen and bone marrow of mice over 7 weeks of age
increased IgM level ( J:142845 )
• mean serum IgM levels are about 2.5 fold higher than in controls
• this phenotype is dependent on the presence of microbes in the housing
increased anti-chromatin antibody level ( J:142845 )
• significant levels of anti-chromatin IgM (about 6 micrograms/ml) and IgG (3 micrograms/ml) are detectable in the sera of mice over 4 months of age
increased inflammatory response ( J:94077 )
• inflammation of the paws
salivary gland inflammation ( J:142845 )
• salivary glands contain hematopoietic cell infiltrates
• this phenotype is dependent on the presence of microbes in the housing
lung inflammation ( J:142845 )
• the lungs contain hematopoietic cell infiltrates
• this phenotype is dependent on the presence of microbes in the housing
decreased susceptibility to bacterial infection ( J:142845 )
• mice have a diminished bacterial burden 2 and 3 days after inoculation with Listeria monocytogenes
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:142845 )
• inoculation with 5x105 CFUs leads to the death of all controls while killing none of the mutant mice

hematopoietic system
enlarged spleen ( J:94077 , J:142845 )
• splenomegaly (J:94077)
• occurs in mice after 6 weeks of age with a mean weight of 98 mg compared to 68 mg (J:142845)
• this phenotype is dependent on the presence of microbes in the housing (J:142845)
increased erythroid progenitor cell number ( J:142845 )
• increase numbers of erythroid cells are found in the spleen though numbers are reduced in the bone marrow
decreased mature B cell number ( J:142845 )
• there is a 40%-50% reduction in the number of mature B cells in the peripheral blood and bone marrow
abnormal myeloid leukocyte morphology ( J:142845 )
• there are an increased number of myeloid cells in the spleen and bone marrow of mice over 7 weeks of age
increased neutrophil cell number ( J:142845 )
• increased numbers of neutrophils are found in the spleen and bone marrow of mice over 7 weeks of age
increased IgM level ( J:142845 )
• mean serum IgM levels are about 2.5 fold higher than in controls
• this phenotype is dependent on the presence of microbes in the housing

respiratory system
lung inflammation ( J:142845 )
• the lungs contain hematopoietic cell infiltrates
• this phenotype is dependent on the presence of microbes in the housing

digestive/alimentary system
salivary gland inflammation ( J:142845 )
• salivary glands contain hematopoietic cell infiltrates
• this phenotype is dependent on the presence of microbes in the housing

endocrine/exocrine glands
salivary gland inflammation ( J:142845 )
• salivary glands contain hematopoietic cell infiltrates
• this phenotype is dependent on the presence of microbes in the housing

integument
integument phenotype ( J:94077 )
N
• normal coat

growth/size/body
enlarged spleen ( J:94077 , J:142845 )
• splenomegaly (J:94077)
• occurs in mice after 6 weeks of age with a mean weight of 98 mg compared to 68 mg (J:142845)
• this phenotype is dependent on the presence of microbes in the housing (J:142845)




Genotype
MGI:3822472
cx2
Allelic
Composition		 Ptpn6m1Btlr/Ptpn6m1Btlr
Stat1m1Btlr/Stat1m1Btlr
Genetic
Background		 C57BL/6J-Stat1m1Btlr Ptpn6m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (49 available)
Stat1m1Btlr mutation (1 available); any Stat1 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
ulcerated autopod ( J:142845 )
• Stat1 deficiency does not prevent the plantar inflammation that is a phenotypic characteristic for Ptpn6m1Btlr homozygotes




Genotype
MGI:3822470
cx3
Allelic
Composition		 Irak4m1Btlr/Irak4m1Btlr
Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic
Background		 C57BL/6J-Ptpn6m1Btlr Irak4m1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak4m1Btlr mutation (2 available); any Irak4 mutation (32 available)
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:142845 )
N
• the plantar inflammation that is a phenotypic characteristic for Ptpn6m1Btlr homozygotes are not found in these mice




Genotype
MGI:3822469
cx4
Allelic
Composition		 Myd88poc/Myd88poc
Ptpn6m1Btlr/Ptpn6m1Btlr
Genetic
Background		 C57BL/6J-Ptpn6m1Btlr Myd88poc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88poc mutation (1 available); any Myd88 mutation (52 available)
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:142845 )
N
• the plantar inflammation and high serum immunoglobulin levels that are phenotypic characteristics for Ptpn6m1Btlr homozygotes are not found in these mice




Genotype
MGI:3822471
cx5
Allelic
Composition		 Ptpn6m1Btlr/Ptpn6m1Btlr
Ticam1Lps2/Ticam1Lps2
Genetic
Background		 C57BL/6J-Ptpn6m1Btlr Ticam1Lps2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn6m1Btlr mutation (1 available); any Ptpn6 mutation (49 available)
Ticam1Lps2 mutation (2 available); any Ticam1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
ulcerated autopod ( J:142845 )
• Ticam1 deficiency does not prevent the plantar inflammation that is a phenotypic characteristic for Ptpn6m1Btlr homozygotes




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory