Phenotypes associated with this allele

• Allele Symbol: Tg(PDGFB-APPSwInd)J9Lms
• Allele Name: transgene insertion J9, Lennart Mucke
• Allele ID: MGI:3717718
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Camk2a-tTA)1Mmay/0 Tg(PDGFB-APPSwInd)J9Lms/0 Tg(tetO-MAPT*A152T)L1Lms/0	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:5828495
tg2	Tg(PDGFB-APPSwInd)J9Lms/0	involves: C57BL/6 * DBA/2	MGI:3784684

Genotype
MGI:5828495

cx1

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(PDGFB-APPSwInd)J9Lms/0; Tg(tetO-MAPT*A152T)L1Lms/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:233816 )

• fewer than the expected numbers (8 of 282) of mice were obtained

• surviving mice do not die before adulthood, with one dying at 7 months, another at 10 months and the remaining being alive at 11-17 months

nervous system

abnormal brain wave pattern ( J:233816 )

• EEG recordings show more abundant epileptic spikes than in controls

Genotype
MGI:3784684

tg2

• Allelic Composition: Tg(PDGFB-APPSwInd)J9Lms/0
• Genetic Background: involves: C57BL/6 * DBA/2

nervous system

amyloid beta deposits ( J:62290 )

• at 5 to 7 months, mice exhibit amloid beta plaques

• between 16 and 21 months, all mice develop amyloid beta plaques

neurodegeneration ( J:62290 )

• neurodegeneration is indicated by an age dependent decrease in density of synaptophysin-immunoreactive presynaptic terminals

homeostasis/metabolism

amyloid beta deposits ( J:62290 )

• at 5 to 7 months, mice exhibit amloid beta plaques

• between 16 and 21 months, all mice develop amyloid beta plaques

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:62290