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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(KRT14-rtTA)208Jek
transgene insertion 208, Jeffrey E Kudlow
MGI:3717751
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Trp53tm1Brd/Trp53tm1Brd
Tg(KRT14-rtTA)208Jek/Y
Tg(tetO-KLF4)32831Rup/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NTac * SJL MGI:3717875
cx2
Trp53tm1Brd/Trp53+
Tg(KRT14-rtTA)208Jek/0
Tg(tetO-KLF4)32831Rup/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NTac * SJL MGI:3717876
cx3
Tg(KRT14-rtTA)208Jek/Y
Tg(tetO-KLF4)32831Rup/0
involves: C57BL/6 * SJL MGI:3717902


Genotype
MGI:3717875
cx1
Allelic
Composition
Trp53tm1Brd/Trp53tm1Brd
Tg(KRT14-rtTA)208Jek/Y
Tg(tetO-KLF4)32831Rup/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-rtTA)208Jek mutation (1 available)
Tg(tetO-KLF4)32831Rup mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (239 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• male animals exhibit epithelial dysplasia associated with infiltration of the dermis by well-vascularized, cellular or fibrotic stroma, or a fibrovascular response upon induction by doxycycline




Genotype
MGI:3717876
cx2
Allelic
Composition
Trp53tm1Brd/Trp53+
Tg(KRT14-rtTA)208Jek/0
Tg(tetO-KLF4)32831Rup/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-rtTA)208Jek mutation (1 available)
Tg(tetO-KLF4)32831Rup mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (239 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• females display focal changes including cystic follicles and mild changes in the adjacent interfollicular epithelium




Genotype
MGI:3717902
cx3
Allelic
Composition
Tg(KRT14-rtTA)208Jek/Y
Tg(tetO-KLF4)32831Rup/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-rtTA)208Jek mutation (1 available)
Tg(tetO-KLF4)32831Rup mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• 9 days of doxycycline treatment to induce KLF4 expression, gland atrophy is observed
• thinning of the pelage of the ventral skin is seen after 3-4 weeks of treatment with doxycycline
• 9 days of doxycycline treatment to induce KLF4 expression, cystic degeneration of hair follicles is seen
• in males, dysplastic phenotype is largely restricted to the ventral skin; dorsal skin is only mildly affected
• females homozygous for Tg(KRT14-rtTA)208Jek display focal changes including cystic follicles and mild changes in the adjacent interfollicular epithelium after 4 weeks of induction
• delayed squamous epithelium maturation is observed after 3-4 weeks of doxycycline treatment in males
• hyperplastic, keratinizing epithelium extends into the dermis
• loss of basal cell polarity seen after 3-4 weeks of doxycycline treatment
• 9 days of doxycycline treatment to induce KLF4 expression, mouse skin shows hyperkeratosis
• 9 days of doxycycline treatment to induce KLF4 expression, epidermal hyperplasia is observed
• crusted skin lesions are evident after 3-4 weeks of doxycycline treatment

endocrine/exocrine glands
• 9 days of doxycycline treatment to induce KLF4 expression, gland atrophy is observed





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory