Analysis Tools
mortality/aging
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• mice survive up to 3 weeks
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skeleton
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• osteoclasts fail to differentiate, as detected by TRAP expression, under culture conditions in which wild-type cells do
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• at day 10, osteoclast numbers in the tibia are reduced
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• long bones exhibit ostepetrosis
• marrow space is reduced by greater than 80% by an abundance of bone and cartilage trabeculae
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• bone density in the trabecular and cortical bone area is increased
• bone volume in the tibia is increased 2.4-fold
• long bones exhibit ostepetrosis
• at day 10, tibia exhibit increased mineralization and mature bone formation
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• at day 10, growth plates have an extended zone of calcified cartilage and the zone of the hypertrophic chondrocytes is increased
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growth/size/body
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• visible at week 1 or 2 after birth
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immune system
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• osteoclasts fail to differentiate, as detected by TRAP expression, under culture conditions in which wild-type cells do
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• at day 10, osteoclast numbers in the tibia are reduced
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limbs/digits/tail
short limbs
(
J:123167
)
hematopoietic system
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• osteoclasts fail to differentiate, as detected by TRAP expression, under culture conditions in which wild-type cells do
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• at day 10, osteoclast numbers in the tibia are reduced
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cellular
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• osteoclasts fail to differentiate, as detected by TRAP expression, under culture conditions in which wild-type cells do
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