About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lhfpl5tm1Kjn
targeted mutation 1, Kenneth R Johnson
MGI:3718054
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lhfpl5tm1Kjn/Lhfpl5tm1Kjn B6.129-Lhfpl5tm1Kjn/Kjn MGI:3718061
ht2
 		Lhfpl5tm1Kjn/Lhfpl5+ B6.129-Lhfpl5tm1Kjn/Kjn MGI:3718082


Genotype
MGI:3718061
hm1
Allelic
Composition		 Lhfpl5tm1Kjn/Lhfpl5tm1Kjn
Genetic
Background		 B6.129-Lhfpl5tm1Kjn/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhfpl5tm1Kjn mutation (1 available); any Lhfpl5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal cochlear inner hair cell morphology ( J:125709 )
• at approximately 1 month of age scanning electron microscopy reveals splayed inner hair cell stereocilia
cochlear outer hair cell degeneration ( J:125709 )
• at approximately 1 month of age scanning electron microscopy reveals disorganized outer hair cell bundles with many degenerated stereocilia
increased or absent threshold for auditory brainstem response ( J:125709 )
• auditory stimuli up to 100 dB SPL fail to elicit ABRs at 34 days of age

behavior/neurological
head tossing ( J:125709 )
• by three weeks of age
bidirectional circling ( J:125709 )
• by three weeks of age

nervous system
nervous system phenotype ( J:125709 )
N
• light microscopic examination of the cranial ganglia does not reveal any gross morphologic abnormalities
abnormal cochlear inner hair cell morphology ( J:125709 )
• at approximately 1 month of age scanning electron microscopy reveals splayed inner hair cell stereocilia
cochlear outer hair cell degeneration ( J:125709 )
• at approximately 1 month of age scanning electron microscopy reveals disorganized outer hair cell bundles with many degenerated stereocilia




Genotype
MGI:3718082
ht2
Allelic
Composition		 Lhfpl5tm1Kjn/Lhfpl5+
Genetic
Background		 B6.129-Lhfpl5tm1Kjn/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhfpl5tm1Kjn mutation (1 available); any Lhfpl5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:125709 )
N
• heterozygotes exhibit normal ABR thresholds at 34 days of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory