Phenotypes associated with this allele

• Allele Symbol: Slc2a4^tm1Jdz
• Allele Name: targeted mutation 1, Jeffrey D Zajac
• Allele ID: MGI:3718071
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc2a4^tm1Jdz/Slc2a4^tm1Jdz	involves: 129S1/Sv * C57BL/6	MGI:3718587
cn2	Slc2a4^tm1Jdz/Slc2a4^tm1Jdz Tg(ACTA1-cre)1Jdz/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3718588

Genotype
MGI:3718587

hm1

• Allelic Composition: Slc2a4^tm1Jdz/Slc2a4^tm1Jdz
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:123335 )

• during hyperinsulinaemic clamp plasma glucose levels are elevated

• however, fasting glucose levels and metabolic glucose clearance are not significantly different from C57BL/6 controls

increased circulating insulin level ( J:123335 )

• insulin levels are more than doubled compared to C57BL/6 controls

cardiovascular system

increased heart weight ( J:123335 )

• about a 15% increase in heart weight (normalized to body weight) compared to C57BL/6 controls

• however, unlike homozygous mice expressing Cre recombinase in muscle tissue, no signs of cardiac hypertrophy are seen

adipose tissue

decreased adipocyte glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in brown adipose tissue

• however, basal glucose uptake is not significantly different from C57BL/6 controls

muscle

decreased skeletal muscle cell glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in white quadriceps tissue

• however, basal glucose uptake is not significantly different from C57BL/6 controls

cellular

decreased adipocyte glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in brown adipose tissue

• however, basal glucose uptake is not significantly different from C57BL/6 controls

decreased skeletal muscle cell glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in white quadriceps tissue

• however, basal glucose uptake is not significantly different from C57BL/6 controls

growth/size/body

increased heart weight ( J:123335 )

• about a 15% increase in heart weight (normalized to body weight) compared to C57BL/6 controls

• however, unlike homozygous mice expressing Cre recombinase in muscle tissue, no signs of cardiac hypertrophy are seen

Genotype
MGI:3718588

cn2

• Allelic Composition: Slc2a4^tm1Jdz/Slc2a4^tm1Jdz; Tg(ACTA1-cre)1Jdz/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

homeostasis/metabolism

increased circulating glucose level ( J:123335 )

• during hyperinsulinaemic clamp plasma glucose levels are elevated

• however, fasting glucose levels and metabolic glucose clearance are not significantly different from C57BL/6 controls

increased circulating insulin level ( J:123335 )

• insulin levels are more than doubled compared to C57BL/6 controls

cardiovascular system

increased heart weight ( J:123335 )

• about an 80% increase in heart weight (normalized to body weight) compared to C57BL/6 controls

cardiac hypertrophy ( J:123335 )

• cardiac hypertrophy not associated with elevation in mean arterial pressure

thick ventricular wall ( J:123335 )

• 65% increase in left and right ventricular wall thickness

cardiac interstitial fibrosis ( J:123335 )

• marked ventricular interstitial fibrosis and fibroblast hyperplasia are seen

increased cardiac muscle cell glucose uptake ( J:123335 )

• basal glucose uptake in the heart is increased

adipose tissue

decreased adipocyte glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in brown adipose tissue

increased adipocyte glucose uptake ( J:123335 )

• basal glucose uptake is increased in white and brown adipose tissue compared to C57BL/6 controls

muscle

increased cardiac muscle cell glucose uptake ( J:123335 )

• basal glucose uptake in the heart is increased

decreased skeletal muscle cell glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in white quadriceps tissue

increased skeletal muscle cell glucose uptake ( J:123335 )

• basal glucose uptake is increased in white quadriceps tissue compared to C57BL/6 controls

cellular

decreased adipocyte glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in brown adipose tissue

increased adipocyte glucose uptake ( J:123335 )

• basal glucose uptake is increased in white and brown adipose tissue compared to C57BL/6 controls

cardiac interstitial fibrosis ( J:123335 )

• marked ventricular interstitial fibrosis and fibroblast hyperplasia are seen

increased cardiac muscle cell glucose uptake ( J:123335 )

• basal glucose uptake in the heart is increased

decreased skeletal muscle cell glucose uptake ( J:123335 )

• during hyperinsulinaemic clamp glucose uptake is reduced in white quadriceps tissue

increased skeletal muscle cell glucose uptake ( J:123335 )

• basal glucose uptake is increased in white quadriceps tissue compared to C57BL/6 controls

growth/size/body

increased heart weight ( J:123335 )

• about an 80% increase in heart weight (normalized to body weight) compared to C57BL/6 controls

cardiac hypertrophy ( J:123335 )

• cardiac hypertrophy not associated with elevation in mean arterial pressure