About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mef2dtm1Eno
targeted mutation 1, Eric N Olson
MGI:3718322
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mef2ctm2Eno/Mef2ctm2Eno
Mef2dtm1Eno/Mef2dtm1Eno
Tg(Col2a1-cre)1Bhr/0 		involves: 129S/SvEv * C57BL/6 * SJL MGI:3719017
cn2
 		Mef2dtm1Eno/Mef2dtm1Eno
Tg(Myog-cre)1Eno/0 		Not Specified MGI:4418150


Genotype
MGI:3719017
cn1
Allelic
Composition		 Mef2ctm2Eno/Mef2ctm2Eno
Mef2dtm1Eno/Mef2dtm1Eno
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2ctm2Eno mutation (0 available); any Mef2c mutation (34 available)
Mef2dtm1Eno mutation (0 available); any Mef2d mutation (66 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
failure of endochondral bone ossification ( J:119152 )
• nearly all mineralized endochondral skeletons are missing




Genotype
MGI:4418150
cn2
Allelic
Composition		 Mef2dtm1Eno/Mef2dtm1Eno
Tg(Myog-cre)1Eno/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2dtm1Eno mutation (0 available); any Mef2d mutation (66 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal skeletal muscle fiber type ratio ( J:127416 )
• slow fibers within the soleus are reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory