Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mef2ctm2Eno targeted mutation 2, Eric N Olson MGI:3718323 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 14 days after immunization with sheep red blood cells (SRBCs)
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• 14 days after immunization with sheep red blood cells (SRBCs)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 14 days after immunization with sheep red blood cells (SRBCs)
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• 14 days after immunization with sheep red blood cells (SRBCs)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduction in slow fibers within the soleus
• loss of type I fibers in the gastrocnemius and plantaris muscles and a decrease in number and intensity of type I fibers in the soleus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• none survive beyond the first week of life
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• some mutants have difficulty breathing, evidenced by gasping and accumulation of air in the intestines
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• truncation of the fibula is severe
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• truncation of the tibia is severe
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• sternum and radius show completely absence of trabeculated bone
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• mutants exhibit severe defects in ossification on nearly all endochondral bones, especially in the sternum
• ossification of the bone collar appears disorganized
• defects in endochondral ossification result from a failure of chondrocyte hypertrophy
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• vertebral bodies and the supraoccipital bone fail to ossify and many phalangeal bones of the digits lack ossification
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• truncation of the fibula is severe
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• truncation of the tibia is severe
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• truncation of all long bones of the limbs
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• structures of the distal ribs, radii, and sternabrae are distorted by disorganized cartilaginous remnants of the growth plate and aberrant ossification
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• absence of ossification of the sternum and a failure in chondrocyte hypertrophy
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• waddling gait due to shortened limbs
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• truncation of all long bones of the limbs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• partial lethality by 5 weeks
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| N |
• mice exhibit normal numbers of spines per length of dendrite in pyramidal neurons
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• 5-fold
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• mice exhibit decreased input-output curve compared with wild-type mice
• however, long term potentiation is normal
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• 5-fold
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• nearly all mineralized endochondral skeletons are missing
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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