Phenotypes associated with this allele

• Allele Symbol: App^tm2Umu
• Allele Name: targeted mutation 2, Ulrike C Muller
• Allele ID: MGI:3718443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm2Umu/App^tm2Umu	involves: 129P2/OlaHsd * C57BL/6	MGI:3718911

Genotype
MGI:3718911

hm1

• Allelic Composition: App^tm2Umu/App^tm2Umu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:123316 )

N • behavioral defects (impaired grip strength, abnormal level and circadian distribution of activity, decreased exploratory behavior under aversive conditions, increased thigmotaxic behavior, reduced swim speed, and impaired spatial learning) seen in null mice are not present in homozygous knock-in mice

nervous system

nervous system phenotype ( J:123316 )

N • long term potentiation is normal, unlike in homozygous null mice

decreased brain weight ( J:123316 )

• brain wet weight is reduced by 3.6% at 10 - 12 months of age

growth/size/body

growth/size/body region phenotype ( J:123316 )

N • body weight is normal, unlike in homozygous null mice