Phenotypes associated with this allele

• Allele Symbol: Tg(Wnt1-En1)1Amc
• Allele Name: transgene insertion 1, Andrew P McMahon
• Allele ID: MGI:3718490
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	En1^tm1Alj/En1^tm1Alj Tg(Wnt1-En1)1Amc/0	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3718801
cx2	En1^tm1Alj/En1^tm1Alj Wnt7a^tm1Amc/Wnt7a^tm1Amc Tg(Wnt1-En1)1Amc/0	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)	MGI:3718802
cx3	En1^tm1Gld/En1^tm1Gld Tg(Wnt1-En1)1Amc/0	involves: 129S/SvEv	MGI:3839920

Genotype
MGI:3718801

cx1

• Allelic Composition: En1^tm1Alj/En1^tm1Alj; Tg(Wnt1-En1)1Amc/0
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:45301 )

• perinatal brain lethality is rescued

nervous system

abnormal brain morphology ( J:45301 )

• brain abnormalities rescued

limbs/digits/tail

abnormal digit morphology ( J:45301 )

• ectopic hair growth on the ventral surface of the anterior digits

• related to ectopic ventral expression of Lmx-1B

abnormal foot pad morphology ( J:45301 )

• dorsal foot pads at the distal tips of digits 2 and 3 in 3 of 7 mice

Genotype
MGI:3718802

cx2

• Allelic Composition: En1^tm1Alj/En1^tm1Alj; Wnt7a^tm1Amc/Wnt7a^tm1Amc; Tg(Wnt1-En1)1Amc/0
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

mortality/aging

premature death ( J:45301 )

• viability ranged from 3 weeks to beyond 4 months

perinatal lethality, incomplete penetrance ( J:45301 )

• born in lower numbers than expected

limbs/digits/tail

abnormal autopod morphology ( J:45301 )

• ventral surface of autopods is pigmented

abnormal digit morphology ( J:45301 )

• dorsal sesamoid processes in the 3rd digit

• no polydactyly

oligodactyly ( J:45301 )

• some mice lack digit 5

abnormal foot pad morphology ( J:45301 )

• ectopic foot pads on digits 2, 3, and 4

• striations on the tips of digits 2, 3, and 5

• hardened foot pads

abnormal forelimb morphology ( J:45301 )

• dorsal surface of forelimbs with ventral surface characteristics

Genotype
MGI:3839920

cx3

• Allelic Composition: En1^tm1Gld/En1^tm1Gld; Tg(Wnt1-En1)1Amc/0
• Genetic Background: involves: 129S/SvEv

behavior/neurological

impaired coordination ( J:106437 )

• impaired ability to walk and maintain balance at higher rotarod speeds

• while performance improves with practice mice never match the performance of wild-type controls