Phenotypes associated with this allele

• Allele Symbol: Siglecg^tm1Lnit
• Allele Name: targeted mutation 1, Lars Nitschke
• Allele ID: MGI:3718495
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Siglecg^tm1Lnit/Siglecg^tm1Lnit	involves: BALB/c	MGI:3718784
cx2	Igh^tm1.1Twin/Igh^tm1.1Twin Siglecg^tm1Lnit/Siglecg^tm1Lnit	involves: 129 * 129S4/SvJae * BALB/c * C57BL/6	MGI:5140414

Genotype
MGI:3718784

hm1

• Allelic Composition: Siglecg^tm1Lnit/Siglecg^tm1Lnit
• Genetic Background: involves: BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal plasma cell differentiation ( J:123353 )

• mice have more extrafollicular IgM-secreting plasma cells

increased B-1 B cell number ( J:123353 )

• B-1 B cell turnover is lower than in wild-type mice

• increases in B cell number occur 1 week after birth

• however, the number of fetal pro-B cells and pre-B cells is normal

increased B-1a cell number ( J:123353 )

• in the spleen and peritoneal cavity, the number of B-1a B cells is increased by up to 9-fold in the peritoneal cavity

increased B-1b cell number ( J:123353 )

• B-1b B cells are increased by 2.5-fold

decreased IgG2a level ( J:123353 )

• following exposure to TNP-ficoll, mice produce less IgG2a

increased IgM level ( J:123353 )

• mice produce 7-fold more serum IgM

• more IgM secreting cells are produced in the spleen and bone marrow

• mice have more extrafollicular IgM-secreting plasma cells

autoimmune response ( J:123353 )

• at 50 and 70 weeks, mice produce more IgM autoantibodies

• however, levels of IgG isotype autoantibodies are normal

hematopoietic system

abnormal plasma cell differentiation ( J:123353 )

• mice have more extrafollicular IgM-secreting plasma cells

increased B-1 B cell number ( J:123353 )

• B-1 B cell turnover is lower than in wild-type mice

• increases in B cell number occur 1 week after birth

• however, the number of fetal pro-B cells and pre-B cells is normal

increased B-1a cell number ( J:123353 )

• in the spleen and peritoneal cavity, the number of B-1a B cells is increased by up to 9-fold in the peritoneal cavity

increased B-1b cell number ( J:123353 )

• B-1b B cells are increased by 2.5-fold

decreased IgG2a level ( J:123353 )

• following exposure to TNP-ficoll, mice produce less IgG2a

increased IgM level ( J:123353 )

• mice produce 7-fold more serum IgM

• more IgM secreting cells are produced in the spleen and bone marrow

• mice have more extrafollicular IgM-secreting plasma cells

Genotype
MGI:5140414

cx2

• Allelic Composition: Igh^tm1.1Twin/Igh^tm1.1Twin; Siglecg^tm1Lnit/Siglecg^tm1Lnit
• Genetic Background: involves: 129 * 129S4/SvJae * BALB/c * C57BL/6

immune system

immune system phenotype ( J:174233 )

N • mice exhibit normal levels of B1a, B1b, and B2 cells