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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ramp2tm1Kmca
targeted mutation 1, Kathleen Caron
MGI:3718497
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ramp2tm1Kmca/Ramp2tm1Kmca involves: 129S6/SvEvTac MGI:3718781
hm2
 		Ramp2tm1Kmca/Ramp2tm1Kmca involves: 129S6/SvEvTac * C57BL/6 MGI:3772942
ht3
 		Ramp2tm1Kmca/Ramp2+ involves: 129S6/SvEvTac MGI:3718783


Genotype
MGI:3718781
hm1
Allelic
Composition		 Ramp2tm1Kmca/Ramp2tm1Kmca
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ramp2tm1Kmca mutation (0 available); any Ramp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:123382 )
• no mice are born alive




Genotype
MGI:3772942
hm2
Allelic
Composition		 Ramp2tm1Kmca/Ramp2tm1Kmca
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ramp2tm1Kmca mutation (0 available); any Ramp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lymphatic endothelial cells of Ramp2tm1Kmca/Ramp2tm1Kmca mice are thin

mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:130930 )
• mice die 1 to 2 days after developing edema

cardiovascular system
abnormal aorta smooth muscle morphology ( J:130930 )
• the vascular smooth muscle lining of the aorta is decreased
abnormal heart right ventricle morphology ( J:130930 )
• the thickness of the compact zone of the right ventricle is decreased compared to in wild-type mice

immune system
abnormal lymph organ development ( J:130930 )
• at E13.5, the jugular lymph sac is smaller than in wild-type mice despite lymphedema
• lymph endothelial cells are thinner and exhibit reduced proliferation compared to lymphatic endothelial cells in wild-type mice
abnormal lymphatic vessel morphology ( J:130930 )
• mice lack a jugular lymphatic trunk
• however, lymphatics vasculature displays normal ultrastructure

homeostasis/metabolism
edema ( J:130930 )
• at E14.5, mice interstitial exhibit edema without hemorrhage

muscle
abnormal aorta smooth muscle morphology ( J:130930 )
• the vascular smooth muscle lining of the aorta is decreased




Genotype
MGI:3718783
ht3
Allelic
Composition		 Ramp2tm1Kmca/Ramp2+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ramp2tm1Kmca mutation (0 available); any Ramp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased litter size ( J:123382 )
• mice yield an average of 2.1 pups per litter compared to an expected litter of 4.5 pups when the lethality of homozygous embryos is taken into account




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory