Phenotypes associated with this allele

• Allele Symbol: Foxp3^tm1Kuch
• Allele Name: targeted mutation 1, Vijay K Kuchroo
• Allele ID: MGI:3718527
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Foxp3^tm1Kuch/? Il6^tm1Kopf/Il6^tm1Kopf	involves: 129S2/SvPas * C57BL/6	MGI:3851995

Genotype
MGI:3851995

cx1

• Allelic Composition: Foxp3^tm1Kuch/?; Il6^tm1Kopf/Il6^tm1Kopf
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:123352 )

• immunization with MOG-peptide leads to less differentiation of Th17 effector cells

• when Treg cells are depleted, Th17 T cells form upon MOG immunization

• nave T cells can be differentiated in vitro to Th17 T cells by incubating with Tgf-beta plus IL-21 albeit to a lesser degree than controls

increased regulatory T cell number ( J:123352 )

• numbers of FoxP3⁺ T cells are increased in MOG-immunized mice compared to immunized controls

• the ratio of MOG-specific Treg to effector T cells is reversed compared to controls

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:123352 )

• mice were confirmed not to produce IL-6

immune system

abnormal CD4-positive T cell differentiation ( J:123352 )

• immunization with MOG-peptide leads to less differentiation of Th17 effector cells

• when Treg cells are depleted, Th17 T cells form upon MOG immunization

• nave T cells can be differentiated in vitro to Th17 T cells by incubating with Tgf-beta plus IL-21 albeit to a lesser degree than controls

increased regulatory T cell number ( J:123352 )

• numbers of FoxP3⁺ T cells are increased in MOG-immunized mice compared to immunized controls

• the ratio of MOG-specific Treg to effector T cells is reversed compared to controls

decreased circulating interleukin-6 level ( J:123352 )

• mice were confirmed not to produce IL-6

decreased interleukin-17 secretion ( J:123352 )

• less IL-17 is secreted when T cells from MOG-challenged mice are presented MOG peptide in vitro

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:123352 )

• mice are resistant to EAE induced by immunization with MOG-peptide