Phenotypes associated with this allele

• Allele Symbol: Gmnn^tm1Nyma
• Allele Name: targeted mutation 1, Keiko Nakayama
• Allele ID: MGI:3718544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gmnn^tm1Nyma/Gmnn^tm1Nyma	involves: C57BL/6	MGI:3718711

Genotype
MGI:3718711

hm1

• Allelic Composition: Gmnn^tm1Nyma/Gmnn^tm1Nyma
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:123394 )

• preimplantation embryos are detected at E3.5; however, all appear abnormal

• no embryos are detected at E7.5 to E13.5

embryo

abnormal preimplantation embryo development ( J:123394 )

• after E1.5, embryo development is retarded and embryos often fail to progress to the 8-cell stage

• at E3.5, embryos exhibit abnormal morphology

• at E3.5, cell and nucleus size are heterogeneous

abnormal inner cell mass morphology ( J:123394 )

• at E3.5, cells of the inner cell mass are dispersed with visible cell boundaries instead of densely aggregated as in wild-type embryos

absent trophectoderm ( J:123394 )

• at E3.5, embryos lack the trophectoderm epithelium

cellular

abnormal cell nucleus morphology ( J:123394 )

• at E3.5, all mice have abnormal nuclei

abnormal cell adhesion ( J:123394 )

• at E3.5, embryonic cells have defective cell-cell adhesion

decreased cell proliferation ( J:123394 )

• at E2.0, fewer cells are undergoing mitosis than in wild-type embryos

• E3.5 cells do not proliferate in culture and fail to enter M phase of mitosis