Phenotypes associated with this allele

• Allele Symbol: Creb3l4^tm1Noj
• Allele Name: targeted mutation 1, Hiroshi Nojima
• Allele ID: MGI:3718553
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Creb3l4^tm1Noj/Creb3l4^tm1Noj	involves: 129S2/SvPas * C57BL/6	MGI:3718710

Genotype
MGI:3718710

hm1

• Allelic Composition: Creb3l4^tm1Noj/Creb3l4^tm1Noj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatid morphology ( J:123396 )

♂ • the nuclei of most epididymal sperm is enlarged

♂ • some sperm head membranes are degraded and nuclei are engulfed by membranes

♂ • some sperm have abnormal hollows in the nuclei and the inner membrane regions, such as of the acrosome or theca, are detached

decreased male germ cell number ( J:123396 )

♂ • male germ cells exhibit an increase in apoptosis compared to in wild-type mice

♂ • however, fertility and fecundity are normal

cellular

abnormal spermatid morphology ( J:123396 )

♂ • some sperm head membranes are degraded and nuclei are engulfed by membranes

♂ • the nuclei of most epididymal sperm is enlarged

♂ • some sperm have abnormal hollows in the nuclei and the inner membrane regions, such as of the acrosome or theca, are detached

decreased male germ cell number ( J:123396 )

♂ • male germ cells exhibit an increase in apoptosis compared to in wild-type mice

♂ • however, fertility and fecundity are normal