Analysis Tools
reproductive system
small testis
(
J:123269
)
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• in adults
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• germ cell numbers are reduced by about 20% at E16.5 and by about 90% from E17.5 onwards
• very few primordial oocytes are present at P0
• numbers of maturing and primordial oocytes are greatly reduced in adults
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• about 70% of seminiferous tubules lack all germ cells while the remainder have only a few spermatogonia and leptotene-like cells
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azoospermia
(
J:123269
)
|
|
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• meiosis is normal until the zygotene stage however very few cells progress to the pachytene stage
• about 20% of pachytene oocytes display perturbed synaptic progression
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• arrest of meiosis in the early pachytene stage with incomplete synaptonemal complex formation
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• all females older than 7 months of age were infertile
• prior to 7 months of age 19 of 22 females were infertile
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• the few fertile females produce smaller litters with some progeny expressing the floxed allele indicating incomplete Cre-mediated recombinatio
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• all males are infertile
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endocrine/exocrine glands
small testis
(
J:123269
)
|
|
• in adults
|
cellular
|
|
• germ cell numbers are reduced by about 20% at E16.5 and by about 90% from E17.5 onwards
• very few primordial oocytes are present at P0
• numbers of maturing and primordial oocytes are greatly reduced in adults
|
|
|
• about 70% of seminiferous tubules lack all germ cells while the remainder have only a few spermatogonia and leptotene-like cells
|
azoospermia
(
J:123269
)
|
|
|
|
|
• meiosis is normal until the zygotene stage however very few cells progress to the pachytene stage
• about 20% of pachytene oocytes display perturbed synaptic progression
|
|
|
• arrest of meiosis in the early pachytene stage with incomplete synaptonemal complex formation
|
