Analysis Tools
skeleton
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• cranial vault is deformed due to premature fusion of the endochondral growth plates
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• growth plate maturation in the sternum and forearm is accelerated, where nearly all chondrocytes in the growth plate are consumed by premature differentiation
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• premature endochondral ossification at E18.5
• growth plates separating the sternebrae are prematurely ossified, resulting in complete ossification along the length of the sternum
• entire vertebrae are ossified due to premature fusion of the growth plates between the vertebral body and the lateral vertebral processes
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craniofacial
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• cranial vault is deformed due to premature fusion of the endochondral growth plates
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limbs/digits/tail
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• growth plate cartilages of the limbs are inappropriately ossified, resulting in distortion of the forelimb
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short limbs
(
J:119152
)
