Phenotypes associated with this allele

• Allele Symbol: Bcl6b^tm2Dent
• Allele Name: targeted mutation 2, Alexander Dent
• Allele ID: MGI:3719094
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl6b^tm2Dent/Bcl6b^tm2Dent	involves: 129/Sv * C57BL/6	MGI:3719161
ht2	Bcl6b^tm2Dent/Bcl6b^+	involves: 129/Sv * C57BL/6	MGI:3719162
cx3	Bcl6b^tm2Dent/Bcl6b^tm2Dent Rag1^tm1Mom/Rag1^tm1Mom	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:3719168
cx4	Bcl6^tm1Sdt/Bcl6^tm1Sdt Bcl6b^tm2Dent/Bcl6b^tm2Dent	involves: 129/Sv * C57BL/6	MGI:3719166

Genotype
MGI:3719161

hm1

• Allelic Composition: Bcl6b^tm2Dent/Bcl6b^tm2Dent
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal blood cell morphology/development ( J:123621 )

• hematopoeitic progenitor cells (HPCs) within the bone marrow strongly decreased and fewer cells are in a proliferative cell cycle

• the number of HPCs in the spleen is increased and more HPCs are actively proliferating

• following stimulation with growth factors and chemokine treatment in vivo, HPCs are unresponsive to chemokine-induced myelosuppression but can be returned to responsiveness by CD8+ T cell depletion

• however, HPCs are sensitive to inhibition of proliferation by TNF-alpha

• depletion of CD4+ or CD8+ T cells increases HPC cycling in the bone marrow

• depletion of CD8+ T cells decreases HPC cycling in the spleen

• the synergistic effect in proliferation observed when HPCs are treated with stem cell factor and granulocyte/macrophage colony stimulating factors is abolished but can be restored by CD8+ T cell depletion

increased erythrocyte cell number ( J:123621 )

• in the peripheral blood leukocytes

decreased neutrophil cell number ( J:123621 )

• in the bone marrow

increased monocyte cell number ( J:123621 )

• in the bone marrow and peripheral blood leukocytes

immune system

decreased neutrophil cell number ( J:123621 )

• in the bone marrow

increased monocyte cell number ( J:123621 )

• in the bone marrow and peripheral blood leukocytes

Genotype
MGI:3719162

ht2

• Allelic Composition: Bcl6b^tm2Dent/Bcl6b⁺
• Genetic Background: involves: 129/Sv * C57BL/6

hematopoietic system

abnormal blood cell morphology/development ( J:123621 )

• mice exhibit an intermediate decrease in hematopoeitic progenitor cells (HPCs) in the bone marrow

• however, cell cycling of HPCs is comparable to that in wild-type mice

Genotype
MGI:3719168

cx3

• Allelic Composition: Bcl6b^tm2Dent/Bcl6b^tm2Dent; Rag1^tm1Mom/Rag1^tm1Mom
• Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

hematopoietic system

abnormal blood cell morphology/development ( J:123621 )

• mice have decreased hematopoeitic progenitor cell (HPC) number and cycling in the spleen compared to in Bcl6b^tm2Dent homozygotes but levels are similar to those in wild-type mice

• mice have decreased HPC number and cycling in the bone marrow similar to in Bcl6b^tm2Dent homozygotes

decreased lymphocyte cell number ( J:123621 )

• mice lack mature lymphocytes

immune system

decreased lymphocyte cell number ( J:123621 )

• mice lack mature lymphocytes

Genotype
MGI:3719166

cx4

• Allelic Composition: Bcl6^tm1Sdt/Bcl6^tm1Sdt; Bcl6b^tm2Dent/Bcl6b^tm2Dent
• Genetic Background: involves: 129/Sv * C57BL/6

growth/size/body

postnatal growth retardation ( J:123621 )

• growth retardation is similar to that seem in Bcl6^tm1Sdt homozygotes

immune system

abnormal immune system physiology ( J:123621 )

• Th2-type inflammation develops spontaneously in the heart and lung