All Phenotypes Bcl6b<tm2Dent> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl6b^tm2Dent
targeted mutation 2, Alexander Dent
MGI:3719094

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl6b^tm2Dent/Bcl6b^tm2Dent	involves: 129/Sv * C57BL/6	MGI:3719161
ht2	Bcl6b^tm2Dent/Bcl6b⁺	involves: 129/Sv * C57BL/6	MGI:3719162
cx3	Bcl6b^tm2Dent/Bcl6b^tm2Dent Rag1^tm1Mom/Rag1^tm1Mom	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:3719168
cx4	Bcl6^tm1Sdt/Bcl6^tm1Sdt Bcl6b^tm2Dent/Bcl6b^tm2Dent	involves: 129/Sv * C57BL/6	MGI:3719166

Allelic Composition	Bcl6b^tm2Dent/Bcl6b^tm2Dent
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6b^tm2Dent mutation (0 available); any Bcl6b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal blood cell morphology/development ( J:123621 )

• hematopoeitic progenitor cells (HPCs) within the bone marrow strongly decreased and fewer cells are in a proliferative cell cycle

• the number of HPCs in the spleen is increased and more HPCs are actively proliferating

• following stimulation with growth factors and chemokine treatment in vivo, HPCs are unresponsive to chemokine-induced myelosuppression but can be returned to responsiveness by CD8+ T cell depletion

• however, HPCs are sensitive to inhibition of proliferation by TNF-alpha

• depletion of CD4+ or CD8+ T cells increases HPC cycling in the bone marrow

• depletion of CD8+ T cells decreases HPC cycling in the spleen

• the synergistic effect in proliferation observed when HPCs are treated with stem cell factor and granulocyte/macrophage colony stimulating factors is abolished but can be restored by CD8+ T cell depletion

increased erythrocyte cell number ( J:123621 )

• in the peripheral blood leukocytes

decreased neutrophil cell number ( J:123621 )

• in the bone marrow

increased monocyte cell number ( J:123621 )

• in the bone marrow and peripheral blood leukocytes

immune system

decreased neutrophil cell number ( J:123621 )

• in the bone marrow

increased monocyte cell number ( J:123621 )

• in the bone marrow and peripheral blood leukocytes

Allelic Composition	Bcl6b^tm2Dent/Bcl6b⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6b^tm2Dent mutation (0 available); any Bcl6b mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal blood cell morphology/development ( J:123621 )

• mice exhibit an intermediate decrease in hematopoeitic progenitor cells (HPCs) in the bone marrow

• however, cell cycling of HPCs is comparable to that in wild-type mice

Allelic Composition	Bcl6b^tm2Dent/Bcl6b^tm2Dent Rag1^tm1Mom/Rag1^tm1Mom
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6b^tm2Dent mutation (0 available); any Bcl6b mutation (16 available)
Rag1^tm1Mom mutation (49 available); any Rag1 mutation (123 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal blood cell morphology/development ( J:123621 )

• mice have decreased hematopoeitic progenitor cell (HPC) number and cycling in the spleen compared to in Bcl6b^tm2Dent homozygotes but levels are similar to those in wild-type mice

• mice have decreased HPC number and cycling in the bone marrow similar to in Bcl6b^tm2Dent homozygotes

decreased lymphocyte cell number ( J:123621 )

• mice lack mature lymphocytes

immune system

decreased lymphocyte cell number ( J:123621 )

• mice lack mature lymphocytes

Allelic Composition	Bcl6^tm1Sdt/Bcl6^tm1Sdt Bcl6b^tm2Dent/Bcl6b^tm2Dent
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6b^tm2Dent mutation (0 available); any Bcl6b mutation (16 available)
Bcl6^tm1Sdt mutation (1 available); any Bcl6 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:123621 )

• growth retardation is similar to that seem in Bcl6^tm1Sdt homozygotes

immune system

abnormal immune system physiology ( J:123621 )

• Th2-type inflammation develops spontaneously in the heart and lung

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