Phenotypes associated with this allele

• Allele Symbol: Bsx^tm2Aoh
• Allele Name: targeted mutation 2, Akihira Ohtoshi
• Allele ID: MGI:3719245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bsx^tm2Aoh/Bsx^tm2Aoh	either: 129S4/SvJae-Bsx^tm2Aoh or (involves: 129S4/SvJae * C57BL/6)	MGI:3720334

Genotype
MGI:3720334

hm1

• Allelic Composition: Bsx^tm2Aoh/Bsx^tm2Aoh
• Genetic Background: either: 129S4/SvJae-Bsx^tm2Aoh or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:123638 )

♀ • precocious involution of the lactating mammary gland occurs

abnormal mammary gland growth during lactation ( J:123638 )

♀ • females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice

♀ • on postpartum day 1, females have less alveoli

lactation failure ( J:123638 )

♀ • mice with homozygous mothers exhibit poor growth due to malnutrition

increased mammary gland apoptosis ( J:123638 )

♀ • females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice

growth/size/body

decreased body size ( J:123638 )

• mice are proportionally smaller than wild-type mice

decreased body weight ( J:123638 )

• after 2 weeks mice weight less than wild-type mice

integument

abnormal involution of the mammary gland ( J:123638 )

♀ • precocious involution of the lactating mammary gland occurs

abnormal mammary gland growth during lactation ( J:123638 )

♀ • females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice

♀ • on postpartum day 1, females have less alveoli

lactation failure ( J:123638 )

♀ • mice with homozygous mothers exhibit poor growth due to malnutrition

increased mammary gland apoptosis ( J:123638 )

♀ • females exhibit increased apoptosis in the postpartum mammary gland relative to wild-type mice

cellular

maternal effect ( J:123638 )

• mice with homozygous mothers fail to reach adulthood

• mice with homozygous mothers exhibit poor growth due to malnutrition