Phenotypes associated with this allele

• Allele Symbol: Trip13^{Gt(RRB047)Byg}
• Allele Name: gene trap RRB047, BayGenomics
• Allele ID: MGI:3719273
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trip13^Gt(RRB047)Byg/Trip13^Gt(RRB047)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3720594

Genotype
MGI:3720594

hm1

• Allelic Composition: Trip13^{Gt(RRB047)Byg}/Trip13^{Gt(RRB047)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Developmental histology of Trip13^{Gt(RRB047)Byg}/Trip13^{Gt(RRB047)Byg} mouse testes

mortality/aging

postnatal lethality, incomplete penetrance ( J:123677 )

• most mice die prior to weaning

reproductive system

decreased oocyte number ( J:123677 )

♀ • most oocytes are lost during late embryogenesis or early in postnatal development

abnormal chiasmata formation ( J:163309 )

• an increased percentage of achiasmate chropmosomes are observed at diplonema in spermatocytes

abnormal chromosomal synapsis ( J:163309 )

• the X and Y are separated at pachynema 7.2-fold more often than in wild-type

abnormal female meiosis ( J:123677 , J:163309 )

♀ • oocytes arrest between pachynema and dictyate (J:123677)

♀ (J:163309)

arrest of male meiosis ( J:123677 , J:163309 )

♂ • sperm arrest during pachytene (J:123677)

♂ • mostly arrest at spermatocyte stages of epithelial stage IV, corresponding to pachynema, a few most-meiotic cells are detected. (J:163309)

♂ • the numbers of crossovers and chiasmata are reduced (J:163309)

♂ • the X and Y fail to form a subnuclear domain (the sex body) during prophase compared to wild-type mice (J:163309)

abnormal synaptonemal complex ( J:163309 )

• total autosomal SC length at pachynema is 11% shorter than in wild-type

immotile sperm ( J:123677 )

♂ • no motile epididymal sperm are observed

abnormal ovary morphology ( J:123677 )

♀ • ovaries are severely dysmorphic and have no or few follicles

absent ovarian follicles ( J:123677 )

♀ • at day 2, mice have no or few follicles

impaired ovarian folliculogenesis ( J:163309 )

♀ • large majority of oocytes are unable to complete folliculogenesis

small ovary ( J:123677 )

♀ • at day 2, ovaries are small and lack oocytes or newly forming follicles

abnormal seminiferous tubule morphology ( J:163309 )

♂ • less populated tubules

small gonad ( J:123677 )

• males and females have small gonads

small testis ( J:123677 , J:163309 )

♂ (J:123677)

♂ • mutant males have significantly smaller testes than wild-type (J:163309)

infertility ( J:123677 , J:163309 )

• males and females are sterile (J:123677)

cellular

decreased oocyte number ( J:123677 )

♀ • most oocytes are lost during late embryogenesis or early in postnatal development

abnormal chiasmata formation ( J:163309 )

• an increased percentage of achiasmate chropmosomes are observed at diplonema in spermatocytes

abnormal chromosomal synapsis ( J:163309 )

• the X and Y are separated at pachynema 7.2-fold more often than in wild-type

abnormal female meiosis ( J:123677 , J:163309 )

♀ • oocytes arrest between pachynema and dictyate (J:123677)

♀ (J:163309)

arrest of male meiosis ( J:123677 , J:163309 )

♂ • sperm arrest during pachytene (J:123677)

♂ • mostly arrest at spermatocyte stages of epithelial stage IV, corresponding to pachynema, a few most-meiotic cells are detected. (J:163309)

♂ • the numbers of crossovers and chiasmata are reduced (J:163309)

♂ • the X and Y fail to form a subnuclear domain (the sex body) during prophase compared to wild-type mice (J:163309)

abnormal synaptonemal complex ( J:163309 )

• total autosomal SC length at pachynema is 11% shorter than in wild-type

immotile sperm ( J:123677 )

♂ • no motile epididymal sperm are observed

abnormal DNA repair ( J:123677 )

• at day 17.5, sperm contain more asynaptic or terminally asynapsed chromosome (62.5% compared to 25% in wild-type mice)

abnormal double-strand DNA break repair ( J:123677 , J:163309 )

• double strand break repair is defective in sperm and oocytes (J:123677)

• early in double-stranded break repair (J:163309)

growth/size/body

decreased body size ( J:123677 )

• surviving mice are smaller in size

limbs/digits/tail

short tail ( J:123677 )

• some surviving mice have shorter tails

kinked tail ( J:123677 )

• some surviving mice have kinked tails

endocrine/exocrine glands

abnormal ovary morphology ( J:123677 )

♀ • ovaries are severely dysmorphic and have no or few follicles

absent ovarian follicles ( J:123677 )

♀ • at day 2, mice have no or few follicles

impaired ovarian folliculogenesis ( J:163309 )

♀ • large majority of oocytes are unable to complete folliculogenesis

small ovary ( J:123677 )

♀ • at day 2, ovaries are small and lack oocytes or newly forming follicles

abnormal seminiferous tubule morphology ( J:163309 )

♂ • less populated tubules

small testis ( J:123677 , J:163309 )

♂ (J:123677)

♂ • mutant males have significantly smaller testes than wild-type (J:163309)

homeostasis/metabolism

abnormal DNA repair ( J:123677 )

• at day 17.5, sperm contain more asynaptic or terminally asynapsed chromosome (62.5% compared to 25% in wild-type mice)

abnormal double-strand DNA break repair ( J:123677 , J:163309 )

• double strand break repair is defective in sperm and oocytes (J:123677)

• early in double-stranded break repair (J:163309)