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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab8atm1.1Aha
targeted mutation 1.1, Akihiro Harada
MGI:3719352
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cdc42tm1Brak/Cdc42+
Rab8atm1.1Aha/Rab8a+
Tg(Vil1-cre)997Gum/0 		involves: C57BL/6J * SJL MGI:5427871
cn2
 		Rab8atm1.1Aha/Rab8atm1.1Aha
Tg(Vil1-cre)997Gum/? 		involves: C57BL/6 * SJL MGI:3720321
cn3
 		Rab8atm1.1Aha/Rab8atm1.2Aha
Tg(Vil1-cre)997Gum/? 		involves: C57BL/6 * SJL MGI:3720322


Genotype
MGI:5427871
cn1
Allelic
Composition		 Cdc42tm1Brak/Cdc42+
Rab8atm1.1Aha/Rab8a+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc42tm1Brak mutation (0 available); any Cdc42 mutation (45 available)
Rab8atm1.1Aha mutation (0 available); any Rab8a mutation (18 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal crypts of Lieberkuhn morphology ( J:184563 )
• greatly expanded or elongated crypts with large lumens and vacuoles
• the inner surfaces of cryptic lumina/values are lined by microvilli
abnormal Paneth cell morphology ( J:184563 )
• electron densities of Paneth cell granules are reduced in crypts
intestinal edema ( J:184563 )
• increase in intestinal tissue weight per surface area, indicating tissue edema
abnormal intestine physiology ( J:184563 )
• mutant intestines exhibit a reduction in glucose uptake compared to either single mutant

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:184563 )
• greatly expanded or elongated crypts with large lumens and vacuoles
• the inner surfaces of cryptic lumina/values are lined by microvilli
abnormal Paneth cell morphology ( J:184563 )
• electron densities of Paneth cell granules are reduced in crypts

homeostasis/metabolism
intestinal edema ( J:184563 )
• increase in intestinal tissue weight per surface area, indicating tissue edema

cellular
abnormal cellular glucose uptake ( J:184563 )
• mutant intestines exhibit a reduction in glucose uptake compared to either single mutant




Genotype
MGI:3720321
cn2
Allelic
Composition		 Rab8atm1.1Aha/Rab8atm1.1Aha
Tg(Vil1-cre)997Gum/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab8atm1.1Aha mutation (0 available); any Rab8a mutation (18 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123415 )
• mice die within 12 weeks of birth




Genotype
MGI:3720322
cn3
Allelic
Composition		 Rab8atm1.1Aha/Rab8atm1.2Aha
Tg(Vil1-cre)997Gum/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab8atm1.1Aha mutation (0 available); any Rab8a mutation (18 available)
Rab8atm1.2Aha mutation (0 available); any Rab8a mutation (18 available)
Tg(Vil1-cre)997Gum mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:123415 )
• mice die along a similar time course (3 to 4 weeks) as Rab8atm1.2Aha homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory