All Phenotypes Aqp9<tm1Nlsn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aqp9^tm1Nlsn
targeted mutation 1, Soren Nielsen
MGI:3719452

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aqp9^tm1Nlsn/Aqp9^tm1Nlsn	involves: 129S1/Sv	MGI:3720623
hm2	Aqp9^tm1Nlsn/Aqp9^tm1Nlsn	involves: 129S1/Sv * C57BL/6	MGI:3720616
cx3	Aqp9^tm1Nlsn/Aqp9^tm1Nlsn Lepr^db/Lepr^db	involves: 129S1/Sv * C57BL/6 * C57BLKS/J	MGI:3720617

Allelic Composition	Aqp9^tm1Nlsn/Aqp9^tm1Nlsn
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp9^tm1Nlsn mutation (1 available); any Aqp9 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to parasitic infection ( J:123305 )

• mice are more resistant to the early stages of P. berghei with all mice alive at day 12 post-infection whereas 50% of wild-type mice survive at this time point

• male mice exhibit a smaller difference in susceptibility compared to wild-type mice

• however, all mice are dead at day 22 of infection

hematopoietic system

abnormal erythrocyte physiology ( J:123305 )

• glycerol permeability is decreased relative to wild-type cells

decreased erythrocyte osmotic fragility ( J:123305 )

• cells are more resistant to glycerol-induced lysis with a half-time of 14 minutes compared to 2.5 minutes for wild-type cells

Allelic Composition	Aqp9^tm1Nlsn/Aqp9^tm1Nlsn
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp9^tm1Nlsn mutation (1 available); any Aqp9 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glycerol level ( J:123742 )

• non-fasting glycerol levels are 530+/-28 compared to 339+/-24 in wild-type mice

• fasting glycerol levels are 493+/-21 compared to 353+/-16 in wild-type mice

increased circulating triglyceride level ( J:123742 )

• non-fasting levels are 0.83+/-0.02 compared to 0.53+/-0.05 in wild-type mice

• fasting levels are 0.74+/-0.03 compared to 0.58+/-0.02 in wild-type mice

Allelic Composition	Aqp9^tm1Nlsn/Aqp9^tm1Nlsn Lepr^db/Lepr^db
Genetic Background	involves: 129S1/Sv * C57BL/6 * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp9^tm1Nlsn mutation (1 available); any Aqp9 mutation (29 available)
Lepr^db mutation (17 available); any Lepr mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:123742 )

• after fasting blood glucose levels are moderately lower than those in Lepr^db homozygotes

increased circulating glycerol level ( J:123742 )

• 939+/-43 compared to 553+/-35 in Lepr^db homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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