All Phenotypes Tgfb1<tm2Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:4943576
cn2	B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺	involves: 129S6/SvEvTac * 129X1/SvJ	MGI:4943571
cn3	Foxp3^tm1Flv/Foxp3⁺ B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tg(Cd4-cre)1Cwi/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3720254
cn4	B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3720255
cn5	Tgfb1^tm2Flv/B9d2/Tgfb1^tm1Flv Tg(CD207-cre)1Dhka/?	involves: 129S6/SvEvTac * C57BL/6J * SJL/J	MGI:3761681

Allelic Composition	B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1^tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Foxp3^{tm4(YFP/icre)Ayr} mutation (2 available); any Foxp3 mutation (58 available)
Tgfb1^tm2Flv mutation (0 available); any Tgfb1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:169839 )

N	• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tg(Cd4-cre)1Cwi mice

hematopoietic system

increased regulatory T cell number ( J:169839 )

• in the peripheral and mesenteric lymph nodes, but not the spleen

• 2-fold increase in mesenteric regulatory T cell

immune system

immune system phenotype ( J:169839 )

N	• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tg(Cd4-cre)1Cwi mice • mice exhibit normal susceptibility to experimental autoimmune encephalomyelitis and Th17 cell differentiation

increased regulatory T cell number ( J:169839 )

• in the peripheral and mesenteric lymph nodes, but not the spleen

• 2-fold increase in mesenteric regulatory T cell

Allelic Composition	B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tnfrsf4^tm2(cre)Nik/Tnfrsf4⁺
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1^tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tgfb1^tm2Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tnfrsf4^tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

colitis ( J:169839 )

• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa

abnormal T cell differentiation ( J:169839 )

• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice

increased T-helper 1 cell number ( J:169839 )

• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice

decreased T-helper 17 cell number ( J:169839 )

• in an experimental autoimmune encephalomyelitis model

increased regulatory T cell number ( J:169839 )

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:169839 )

• almost complete resistance

liver inflammation ( J:169839 )

• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice

lung inflammation ( J:169839 )

• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice

growth/size/body

cachexia ( J:169839 )

• mild beginning at 5 months

digestive/alimentary system

abnormal enterocyte proliferation ( J:169839 )

• slight hyperplasia

colitis ( J:169839 )

• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa

liver/biliary system

liver inflammation ( J:169839 )

• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice

respiratory system

lung inflammation ( J:169839 )

• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice

hematopoietic system

abnormal T cell differentiation ( J:169839 )

• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice

increased T-helper 1 cell number ( J:169839 )

• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice

decreased T-helper 17 cell number ( J:169839 )

• in an experimental autoimmune encephalomyelitis model

increased regulatory T cell number ( J:169839 )

cellular

abnormal enterocyte proliferation ( J:169839 )

• slight hyperplasia

Allelic Composition	Foxp3^tm1Flv/Foxp3⁺ B9d2/Tgfb1^tm1Flv/Tgfb1^tm2Flv Tg(Cd4-cre)1Cwi/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1^tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Foxp3^tm1Flv mutation (3 available); any Foxp3 mutation (58 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tgfb1^tm2Flv mutation (0 available); any Tgfb1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased regulatory T cell number ( J:123547 )

• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice

• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon

• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis

hematopoietic system

increased regulatory T cell number ( J:123547 )

• Foxp3+ regulatory T cells are increased 2-fold relative to wild-type mice

• the numbers of regulatory T cells is increased in the peripheral and mesenteric lymph nodes, spleens and among the lamina propria mononuclear cell infiltrate of the colon

• proliferation of Foxp3+ cells and CD4+CD8+Foxp3- cells is increased in association with the development of colitis

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:123547 )

• mice begin to die at 6 months of age due to wasting and diarrhea

immune system

abnormal T cell differentiation ( J:123547 )

• T cells Th1, Th2 and CTL (cytotoxic T lymphocyte) differentiation is enhanced while Th17-cell differentiation is inhibited

• in the experimental autoimmune encephalomyelitis model, the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis

abnormal T-helper 17 cell differentiation ( J:169839 )

• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner

abnormal T cell activation ( J:123547 )

• T cell activation is enhanced

increased T cell proliferation ( J:123547 )

abnormal interferon level ( J:123547 )

• following activation, interferon-gamma levels are increased relative to in control cells

• in the experimental autoimmune encephalomyelitis model, only mice that develop encephalomyelitis produce great amounts of interferon-gamma

abnormal interleukin level ( J:123547 )

• following activation, IL-4 levels are increased whereas IL-17 levels are decreased relative to in control cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:123547 )

• 6 of 8 mice did not develop encephalomyelitis and only 2 showed mild disease compared to controls which all develop severe disease

• the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis

• only mice that develop encephalomyelitis produce great amounts of interferon-gamma

increased anti-nuclear antigen antibody level ( J:123547 )

increased anti-double stranded DNA antibody level ( J:123547 )

abnormal inflammatory response ( J:123547 )

• mice present with mononuclear infiltrate in the lungs, parenchyma of the liver, and colon

colitis ( J:123547 )

• severe colitis is associated with disruption of the crypt architecture, crypt abscess formation and epithelium hyperplasia

digestive/alimentary system

diarrhea ( J:123547 )

• at 4 months of age

abnormal intestinal epithelium morphology ( J:123547 )

• epithelium hyperplasia is associated with colitis

abnormal crypts of Lieberkuhn morphology ( J:123547 )

• disruption of crypt architecture is associated with colitis

crypts of Lieberkuhn abscesses ( J:123547 )

• associated with colitis

abnormal colon morphology ( J:123547 )

• at 4 to 12 months of age, heavy mononuclear cell infiltrate of the lamina propria and subglandular areas of the colon is detected

colitis ( J:123547 )

• severe colitis is associated with disruption of the crypt architecture, crypt abscess formation and epithelium hyperplasia

growth/size/body

cachexia ( J:123547 )

• at 4 months of age mice display signs of wasting

liver/biliary system

abnormal hepatocyte morphology ( J:123547 )

• mononuclear cell clusters are detected in the parenchyma of mice with colitis

renal/urinary system

renal glomerular immunoglobulin deposits ( J:123547 )

• IgG deposits accumulate in the glomeruli

respiratory system

abnormal lung morphology ( J:123547 )

• mononuclear cell infiltrate is present in the lungs of mice with colitis

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:123547 )

• disruption of crypt architecture is associated with colitis

crypts of Lieberkuhn abscesses ( J:123547 )

• associated with colitis

hematopoietic system

abnormal T cell differentiation ( J:123547 )

• T cells Th1, Th2 and CTL (cytotoxic T lymphocyte) differentiation is enhanced while Th17-cell differentiation is inhibited

• in the experimental autoimmune encephalomyelitis model, the number of IL-17 producing T cells is reduced in animals that do and those that do not develop encephalomyelitis

abnormal T-helper 17 cell differentiation ( J:169839 )

• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner

abnormal T cell activation ( J:123547 )

• T cell activation is enhanced

increased T cell proliferation ( J:123547 )

homeostasis/metabolism

abnormal interferon level ( J:123547 )

• following activation, interferon-gamma levels are increased relative to in control cells

• in the experimental autoimmune encephalomyelitis model, only mice that develop encephalomyelitis produce great amounts of interferon-gamma

abnormal interleukin level ( J:123547 )

• following activation, IL-4 levels are increased whereas IL-17 levels are decreased relative to in control cells

cellular

increased T cell proliferation ( J:123547 )

Allelic Composition	Tgfb1^tm2Flv/B9d2/Tgfb1^tm1Flv Tg(CD207-cre)1Dhka/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1^tm1Flv mutation (0 available); any Tgfb1 mutation (35 available)
Tg(CD207-cre)1Dhka mutation (1 available)
Tgfb1^tm2Flv mutation (0 available); any Tgfb1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased Langerhans cell number ( J:126147 )

• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1^tm1Flv mice

hematopoietic system

decreased Langerhans cell number ( J:126147 )

• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1^tm1Flv mice

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