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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		B9d2/Tgfb1tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3719621
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		B9d2/Tgfb1tm1Flv/B9d2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:4943575
cn2
 		B9d2/Tgfb1tm1Flv/B9d2+
Tnfrsf4tm2(cre)Nik/Tnfrsf4+ 		involves: 129S6/SvEvTac * 129X1/SvJ MGI:4943570
cn3
 		B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/? 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:3720258
cn4
 		B9d2/Tgfb1tm1Flv/B9d2+
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:4943572
cn5
 		B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/0 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5544320
cn6
 		B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761680
cn7
 		B9d2/Tgfb1tm1Flv/B9d2+
Tg(CD207-cre)1Dhka/? 		involves: 129S6/SvEvTac * C57BL/6J * SJL/J MGI:3761682


Genotype
MGI:4943575
cn1
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2+
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:169839 )
N
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice
• mice exhibit normal susceptibility to experimental autoimmune encephalomyelitis and Th17 cell differentiation
increased regulatory T cell number ( J:169839 )
• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell

growth/size/body
growth/size/body region phenotype ( J:169839 )
N
• mice do not exhibit wasting or inflammation unlike B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv Tg(Cd4-cre)1Cwi mice

hematopoietic system
increased regulatory T cell number ( J:169839 )
• in the peripheral and mesenteric lymph nodes, but not the spleen
• 2-fold increase in mesenteric regulatory T cell




Genotype
MGI:4943570
cn2
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2+
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
colitis ( J:169839 )
• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa
abnormal T cell differentiation ( J:169839 )
• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
increased T-helper 1 cell number ( J:169839 )
• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
decreased T-helper 17 cell number ( J:169839 )
• in an experimental autoimmune encephalomyelitis model
liver inflammation ( J:169839 )
• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice
lung inflammation ( J:169839 )
• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice

growth/size/body
cachexia ( J:169839 )
• mild beginning at 5 months

digestive/alimentary system
abnormal enterocyte proliferation ( J:169839 )
• slight hyperplasia
colitis ( J:169839 )
• mild beginning at 5 months with mononuclear cell infiltrates in the mucosal lamina propria of the colon, with slight epithelial hyperplasia, and increased numbers of leukocytes in the mucosa

liver/biliary system
liver inflammation ( J:169839 )
• mice exhibit small foci of infiltrating mononuclear cells in the liver parenchyma unlike wild-type mice

respiratory system
lung inflammation ( J:169839 )
• mice exhibit small foci of infiltrating mononuclear cells in the lung unlike wild-type mice

hematopoietic system
abnormal T cell differentiation ( J:169839 )
• mice exhibit only marginally enhanced activation and differentiation of T cells in the peripheral lymph nodes, spleen, and mesenteric lymph nodes compared with wild-type mice
increased T-helper 1 cell number ( J:169839 )
• intraepithelial lymphocytes from the small intestine exhibit a high frequency of IFN-gamma-producing Th1 cells compared with wild-type mice
decreased T-helper 17 cell number ( J:169839 )
• in an experimental autoimmune encephalomyelitis model

cellular
abnormal enterocyte proliferation ( J:169839 )
• slight hyperplasia




Genotype
MGI:3720258
cn3
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal inflammatory response ( J:123547 )
• mice present with a similar inflammatory disorder as seen in B9d2/Tgfb1tm1Flv/ Tgfb1tm2Flv Tg(CD4-cre)1Cwi mice




Genotype
MGI:4943572
cn4
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T-helper 17 cell differentiation ( J:169839 )
• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner

immune system
abnormal T-helper 17 cell differentiation ( J:169839 )
• as determined by transplantation experiments, defects in Th17 cell differentiation occur in an autocrine manner




Genotype
MGI:5544320
cn5
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal regulatory T cell physiology ( J:204761 )
• regulatory T cells fail to drive Th17 differentiation

immune system
abnormal regulatory T cell physiology ( J:204761 )
• regulatory T cells fail to drive Th17 differentiation




Genotype
MGI:3761680
cn6
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(CD207-cre)1Dhka mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• although the number of Langerhans cells is substantially reduced compared to in wild-type mice, a variable number of Langerhans cells are present in the epidermis (0.02% to 0.1% of total epidermal cells compared to 0.42% to 1.17% in wild-type mice)
• Langerhans cells are absent from the vast majority of the ear with Langerhans cells being found at the edge of the ear in clusters




Genotype
MGI:3761682
cn7
Allelic
Composition		 B9d2/Tgfb1tm1Flv/B9d2+
Tg(CD207-cre)1Dhka/?
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B9d2/Tgfb1tm1Flv mutation (0 available); any B9d2 mutation (13 available)
Tg(CD207-cre)1Dhka mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased Langerhans cell number ( J:126147 )
• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice

hematopoietic system
decreased Langerhans cell number ( J:126147 )
• mice are indistinguishable from Tg(CD207-cre)1Mjs B9d2/Tgfb1tm1Flv mice




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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory