Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-cre/ERT2,-EYFP)VGfng
• Allele Name: transgene insertion V, Guoping Feng
• Allele ID: MGI:3719909
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^+ Tg(Thy1-cre/ERT2,-EYFP)VGfng/0	involves: C57BL/6 * SJL	MGI:3719920
cn2	Srgap3^tm1Ssod/Srgap3^tm1.1Ssod Tg(Thy1-cre/ERT2,-EYFP)VGfng/0	involves: C57BL/6 * SJL	MGI:4941466
cn3	Arpc3^tm1Ssod/Arpc3^tm1Ssod Gt(ROSA)26Sor^tm2(CAG-tdTomato)Fawa/Gt(ROSA)26Sor^+ Tg(Thy1-cre/ERT2,-EYFP)VGfng/0	involves: C57BL/6 * SJL	MGI:5509192

Genotype
MGI:3719920

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺; Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122791 )

• mice are viable and express LacZ in cells where cre is expressed

Genotype
MGI:4941466

cn2

• Allelic Composition: Srgap3^tm1Ssod/Srgap3^tm1.1Ssod; Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
• Genetic Background: involves: C57BL/6 * SJL

nervous system

nervous system phenotype ( J:169533 )

N • tamoxifen-treated mice exhibit normal spine density

Genotype
MGI:5509192

cn3

• Allelic Composition: Arpc3^tm1Ssod/Arpc3^tm1Ssod; Gt(ROSA)26Sor^{tm2(CAG-tdTomato)Fawa}/Gt(ROSA)26Sor⁺; Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
• Genetic Background: involves: C57BL/6 * SJL

nervous system

abnormal dendritic spine morphology ( J:196577 )

• by 4 and 8 weeks after tamoxifen treatment, neurons exhibit a progressive reduction of spine density in the stratum radiatum compared with control neurons

• tamoxifen-treated neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons