nervous system
N |
• no cerebral amyloid beta deposition is detected
|
• neurons in the brain, liver cells, intestinal epithelial cells, skeletal and heart muscle fibers, and adrenal gland contain detectable amounts of amyloid beta, and pancreatic acinar cells show highest levels
• all transgenic mice over 8 months of age show amyloid accumulation, particularly in the pancreas
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endocrine/exocrine glands
• some pancreatic acinar cells show degeneration with vacuoles; these cells appear to have inclusion body-like deposits
• in cytoplasm of acinar cells, vacuoles contain numerous nonbranching amyloid fibrils; such fibrils are also observed in large amounts in interstitial macrophages
• vacuoles also contain membranous debris and small vesicles
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digestive/alimentary system
• some pancreatic acinar cells show degeneration with vacuoles; these cells appear to have inclusion body-like deposits
• in cytoplasm of acinar cells, vacuoles contain numerous nonbranching amyloid fibrils; such fibrils are also observed in large amounts in interstitial macrophages
• vacuoles also contain membranous debris and small vesicles
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immune system
• in plasma, levels of Abeta 1-40 and Abeta 1-42 are 30-fold higher than in wild-type plasma
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homeostasis/metabolism
• neurons in the brain, liver cells, intestinal epithelial cells, skeletal and heart muscle fibers, and adrenal gland contain detectable amounts of amyloid beta, and pancreatic acinar cells show highest levels
• all transgenic mice over 8 months of age show amyloid accumulation, particularly in the pancreas
|
• in plasma, levels of Abeta 1-40 and Abeta 1-42 are 30-fold higher than in wild-type plasma
|