Phenotypes associated with this allele

• Allele Symbol: Kcnj8^mydy
• Allele Name: mayday
• Allele ID: MGI:3720053
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnj8^mydy/Kcnj8^mydy	involves: C57BL/6J	MGI:3761932

Genotype
MGI:3761932

hm1

• Allelic Composition: Kcnj8^mydy/Kcnj8^mydy
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:126658 )

• 4 of 9 mice die within 24 hours or receiving 2 rounds of 5.5 Gy radiation

increased susceptibility to induced morbidity/mortality ( J:126658 )

• mice die when injected with 20 ug of poly(IC) whereas no similarly treated wild-type mice dies

• 13 of 15 mice die when injected with 127 ug of CpG DNA whereas no similarly treated wild-type mice dies

• mice often die when injected with 1.5 ml thioglycolate

immune system

increased susceptibility to endotoxin shock ( J:126658 )

• 10% of mice die following injection of 10 ng of LPS whereas the median lethal dose for wild-type mice is more than 200 ug per 20 g body weight

increased susceptibility to Herpesvirales infection ( J:126658 )

• mice die between 24 and 72 hours after infection with mouse cytomegalovirus without high titers of virus or evidence of antecedent sickness

• cytokine response following infection with mouse cytomegalovirus is lower than normal

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:126658 )

• 4 of 9 mice die within 24 hours or receiving 2 rounds of 5.5 Gy radiation