Phenotypes associated with this allele

• Allele Symbol: Mtm1^tm1.2Jman
• Allele Name: targeted mutation 1.2, Jean-Louis Mandel
• Allele ID: MGI:3720064
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mtm1^tm1.2Jman/Y Tg(ACTA1-cre)79Jme/?	involves: 129T1/Sv * C57BL/6 * SJL	MGI:3720805
cn2	Mtm1^tm1.2Jman/Y Tg(Eno2-cre)39Jme/?	involves: 129T1/Sv * C57BL/6 * SJL	MGI:3720806

Genotype
MGI:3720805

cn1

• Allelic Composition: Mtm1^tm1.2Jman/Y; Tg(ACTA1-cre)79Jme/?
• Genetic Background: involves: 129T1/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:81791 )

♂ • similar phenotype compared to hemizygous male Mtm1^tm1.1Jman mice

growth/size/body

postnatal growth retardation ( J:81791 )

♂ • a very similar phenotype compared to hemizygous male Mtm1^tm1.1Jman mice showing progressive growth impairment starting at 4 weeks of age

muscle

skeletal muscle fiber atrophy ( J:81791 )

♂ • similar phenotype compared to hemizygous male Mtm1^tm1.1Jman mice, many atrophic myofibers are seen by histological analyses

centrally nucleated skeletal muscle fibers ( J:81791 )

♂ • similar phenotype compared to hemizygous male Mtm1^tm1.1Jman mice, many atrophic myofibers that contain centrally located nuclei are seen by histological analyses

myopathy ( J:81791 )

♂ • a very similar phenotype compared to hemizygous male Mtm1^tm1.1Jman mice starting at 4 weeks of age in the hindlimbs, that becomes generalized at 5 weeks

Genotype
MGI:3720806

cn2

• Allelic Composition: Mtm1^tm1.2Jman/Y; Tg(Eno2-cre)39Jme/?
• Genetic Background: involves: 129T1/Sv * C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:81791 )

♂ • no obvious clinical symptom followed up to 14 weeks of age

♂ • no lesions were observed in muscle by histological analyses