Analysis Tools
mortality/aging
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• 69% of transgenic mice die within the first year of life, compared to 7% of nontransgenic littermates; first death occurred at 30 days of age
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behavior/neurological
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• seizures are very rare or absent in these mice compared to transgenics on the FVB background
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nervous system
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• seizures are very rare or absent in these mice compared to transgenics on the FVB background
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• numerous apoptotic cells are observed in the granular layer of the dentate gyrus
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• nuclei of glial cells in corpus callosum and fimbria appear rounded rather than ellipsoid
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astrocytosis
(
J:32213
)
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• already present in younger mice, even in absence of seizures
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• neurons in the brain appear abnormal upon post-mortem; many are vacuolized, or contain clear cytoplasm around compacted and densely stained nuclei, and are usually found on the boundary of the granule layer and hilus of dentate gyrus and throughout granule layer of dentate gyrus
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• degenerating neurons are present in thalamus and posterior cingulate cortex, caudate putamen, hypothalamus and CA1 and CA2 region of pyramidal layer of hippocampus
• more severe than in lines 4 or 6
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hematopoietic system
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• nuclei of glial cells in corpus callosum and fimbria appear rounded rather than ellipsoid
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immune system
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• nuclei of glial cells in corpus callosum and fimbria appear rounded rather than ellipsoid
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cellular
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• numerous apoptotic cells are observed in the granular layer of the dentate gyrus
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