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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-MAPT)5Vln
transgene insertion 5, Fred Van Leuven
MGI:3720115
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan
Tg(Thy1-MAPT)5Vln/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4950910
tg2
 		Tg(Thy1-MAPT)5Vln/Tg(Thy1-MAPT)5Vln involves: FVB MGI:3720207


Genotype
MGI:4950910
cx1
Allelic
Composition		 Ppp2r5dtm1Vjan/Ppp2r5dtm1Vjan
Tg(Thy1-MAPT)5Vln/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp2r5dtm1Vjan mutation (0 available); any Ppp2r5d mutation (34 available)
Tg(Thy1-MAPT)5Vln mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavior ( J:171339 )
• mice take more time to remove an adhesive sticker than Tg(Thy1-MAPT)5Vln mice
impaired coordination ( J:171339 )
• in beam walk and rotatrod tests to a greater extent than in either Ppp2r5dtm1Vjan homozygotes or Tg(Thy1-MAPT)5Vln mice
decreased thermal nociceptive threshold ( J:171339 )
• compared with Tg(Thy1-MAPT)5Vln mice




Genotype
MGI:3720207
tg2
Allelic
Composition		 Tg(Thy1-MAPT)5Vln/Tg(Thy1-MAPT)5Vln
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:100972 )
• dilated axons are observed in brain and spinal cord

behavior/neurological
impaired coordination ( J:100972 )
• compared to wild-type mice, mutants are 5 times more likely to fall off of a rotating rod in a rotarod test




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory