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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr5a2tm1Sjns
targeted mutation 1, Kristina Schoonjans
MGI:3720193
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Albtm1(cre/ERT2)Mtz/Alb+
Nr5a2tm1Sjns/Nr5a2tm1Sjns 		involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3769251
cn2
 		Ldlrtm1Her/Ldlrtm1Her
Nr5a2tm1Sjns/Nr5a2tm1Sjns
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA MGI:5607406
cn3
 		Nr5a2tm1Sjns/Nr5a2tm1Sjns
Tg(Vil1-cre/ERT2)23Syr/? 		involves: 129/Sv * C57BL/6 * DBA/2 * SJL MGI:3721528


Genotype
MGI:3769251
cn1
Allelic
Composition		 Albtm1(cre/ERT2)Mtz/Alb+
Nr5a2tm1Sjns/Nr5a2tm1Sjns
Genetic
Background		 involves: 129/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Albtm1(cre/ERT2)Mtz mutation (2 available); any Alb mutation (97 available)
Nr5a2tm1Sjns mutation (0 available); any Nr5a2 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased feces bile salt level ( J:129068 )
• following treatment with tamoxifen, bile acid in the feces is almost doubled in Nr5a2tm2Sjns homozygotes due to an increase in lithocholic acid and hydrophobic secondary bile acids produced in the intestine by bacteria
abnormal intestinal lipid absorption ( J:129068 )
• following treatment with tamoxifen, mice exhibit lipid malabsorption
abnormal bile salt level ( J:129068 )
• following treatment with tamoxifen, the bile acid pool size is reduced as is the levels in the livers /gallbladders and intestines due to a reduction in cholic acid and tauroconjugated cholic acid while the levels of muricholic acid, ursodeoxycholic acid and their taurine conjugates are increased

digestive/alimentary system
abnormal feces composition ( J:129068 )
• following treatment with tamoxifen, feces lipid and bile acid content is increased
increased feces bile salt level ( J:129068 )
• following treatment with tamoxifen, bile acid in the feces is almost doubled in Nr5a2tm2Sjns homozygotes due to an increase in lithocholic acid and hydrophobic secondary bile acids produced in the intestine by bacteria
abnormal intestinal lipid absorption ( J:129068 )
• following treatment with tamoxifen, mice exhibit lipid malabsorption




Genotype
MGI:5607406
cn2
Allelic
Composition		 Ldlrtm1Her/Ldlrtm1Her
Nr5a2tm1Sjns/Nr5a2tm1Sjns
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (81 available)
Nr5a2tm1Sjns mutation (0 available); any Nr5a2 mutation (96 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:215556 )
N
• mice fed a high-cholesterol diet for 12 weeks exhibit a similar body and liver weight as single Ldlr homozygotes and do not develop increased atherosclerosis

digestive/alimentary system
abnormal feces lipid level ( J:215556 )
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygote

homeostasis/metabolism
abnormal feces lipid level ( J:215556 )
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygote
abnormal sterol level ( J:215556 )
• reverse cholesterol transport analysis indicates an increase in fecal sterol content compared to single Ldlr homozygotes




Genotype
MGI:3721528
cn3
Allelic
Composition		 Nr5a2tm1Sjns/Nr5a2tm1Sjns
Tg(Vil1-cre/ERT2)23Syr/?
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a2tm1Sjns mutation (0 available); any Nr5a2 mutation (96 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
colonic necrosis ( J:123697 )
• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis results in severe lesions with advanced necrosis
increased susceptibility to induced colitis ( J:123697 )
• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis is more severe than in wild-type mice

immune system
increased susceptibility to induced colitis ( J:123697 )
• following treatment with tamoxifen, 2,4,6-trinitrobezene sulfonic acid (TNBS)-induced colitis is more severe than in wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory