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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pdcd1lg2tm2Shr
targeted mutation 2, Arlene H Sharpe
MGI:3720327
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pdcd1lg2tm2Shr/Pdcd1lg2tm2Shr C.B6-Pdcd1lg2tm2Shr MGI:3721512


Genotype
MGI:3721512
hm1
Allelic
Composition
Pdcd1lg2tm2Shr/Pdcd1lg2tm2Shr
Genetic
Background
C.B6-Pdcd1lg2tm2Shr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdcd1lg2tm2Shr mutation (1 available); any Pdcd1lg2 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• bone marrow dendritic cells increases the production of IL-2 and interferon-gamma from transgenic DO11 T cells in vitro by 20% to 50% when compared to wild-type cells
• in an in vitro assay with dendritic cell or an adoptive transfer experiment into mice, DO11 transgenic T cells are modestly stimulated to over-produce interferon-gamma
• in an in vitro assay with dendritic cell or an adoptive transfer experiment into mice, DO11 transgenic T cells are modestly stimulated to over-produce IL-2
• in an adoptive transfer experiment into mice, IL-4+ DO11 transgenic cells are reduced by 60%





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory