Phenotypes associated with this allele

• Allele Symbol: Gata3^tm1.2Mbu
• Allele Name: targeted mutation 1.2, Meinrad Busslinger
• Allele ID: MGI:3720332
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata3^tm1.2Mbu/Gata3^tm1.2Mbu	C3.129P2-Gata3^tm1.2Mbu	MGI:3720335

Genotype
MGI:3720335

hm1

• Allelic Composition: Gata3^tm1.2Mbu/Gata3^tm1.2Mbu
• Genetic Background: C3.129P2-Gata3^tm1.2Mbu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:104408 )

• mice die around E11

renal/urinary system

absent ureteric bud ( J:104408 )

• at E10.5, the ureteric bud is absent

embryo

abnormal mesonephros morphology ( J:104408 )

• at the 17-somite stage, the mesonephros, identified by Pax2 staining, is delayed in its caudal extension

• at 27 somites, only a single and discontinuous row of Pax2+ cells reaches the tip of the tail

abnormal Wolffian duct morphology ( J:104408 )

• at E9.25, swelling in the nephric duct is apparent

• at E9.5, the nephric duct is absent and the nephric cord undergoes apoptosis

• at E9.5 to E10.5, ectopic nephric ducts grow towards the surface ectoderm

• at E10.5, the nephric duct and ureteric bud are absent

• in about 65% of mice, the nephric duct initiates caudal extension but moves away from the nephric cord and fuses to surface ectoderm

• no nephric ducts reach the cloaca

• nephric ducts contain 2.6-fold more cells than in wild-type mice and undergo a 4.6-fold increase in proliferation relative to wild-type mice

absent Wolffian ducts ( J:104408 )

• at E9.5, the nephric duct is absent and the nephric cord undergoes apoptosis

• at E10.5, the nephric duct is absent