Phenotypes associated with this allele

• Allele Symbol: Il25^tm1Dart
• Allele Name: targeted mutation 1, David Artis
• Allele ID: MGI:3720348
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il25^tm1Dart/Il25^tm1Dart	C57BL/6-Il25^tm1Dart	MGI:3721438
hm2	Il25^tm1Dart/Il25^tm1Dart	involves: C57BL/6	MGI:3763121

Genotype
MGI:3721438

hm1

• Allelic Composition: Il25^tm1Dart/Il25^tm1Dart
• Genetic Background: C57BL/6-Il25^tm1Dart

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

intestinal inflammation ( J:123808 )

• chronically infected mice exhibit severe intestinal inflammation with transmural infiltrate of lymphocytes, crypt elongation, and disrupted intestinal architecture

decreased IgG2a level ( J:123808 )

• following infection with Trichuris muris, IgG2a levels are decreased

abnormal interferon level ( J:123808 )

• chronically infected mice have elevated levels of interferon-gamma

abnormal interleukin level ( J:123808 )

• chronically infected mice have elevated levels of IL-17

abnormal response to infection ( J:123808 )

• following infection with Trichuris muris, IgG2a levels are decreased and mice do not exhibit goblet cell hyperplasia as do infected wild-type mice

• chronically infected mice exhibit severe intestinal inflammation with transmural infiltrate of lymphocytes, crypt elongation, disrupted intestinal architecture, a complete absence of goblet cells, and elevated levels of interferon-gamma and IL-17

increased susceptibility to parasitic infection ( J:123808 )

• following infection with Trichuris muris, mice fail to clear worms by day 20 as in infected wild-type mice

digestive/alimentary system

abnormal intestinal goblet cell morphology ( J:123808 )

• following infection with Trichuris muris, mice do not exhibit goblet cell hyperplasia as infected wild-type mice do

• chronically infected mice exhibit a complete absence of goblet cells

abnormal crypts of Lieberkuhn morphology ( J:123808 )

• chronically infected mice exhibit crypt elongation

intestinal inflammation ( J:123808 )

• chronically infected mice exhibit severe intestinal inflammation with transmural infiltrate of lymphocytes, crypt elongation, and disrupted intestinal architecture

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:123808 )

• chronically infected mice exhibit crypt elongation

homeostasis/metabolism

abnormal interferon level ( J:123808 )

• chronically infected mice have elevated levels of interferon-gamma

abnormal interleukin level ( J:123808 )

• chronically infected mice have elevated levels of IL-17

hematopoietic system

decreased IgG2a level ( J:123808 )

• following infection with Trichuris muris, IgG2a levels are decreased

cellular

abnormal intestinal goblet cell morphology ( J:123808 )

• following infection with Trichuris muris, mice do not exhibit goblet cell hyperplasia as infected wild-type mice do

• chronically infected mice exhibit a complete absence of goblet cells

Genotype
MGI:3763121

hm2

• Allelic Composition: Il25^tm1Dart/Il25^tm1Dart
• Genetic Background: involves: C57BL/6

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:125296 )

• following immunization with myelin oligodendrocyte glycoprotein and CFA, all mice die by day 17 whereas wild-type mice survive

immune system

increased T cell number ( J:125296 )

• following immunization with myelin oligodendrocyte glycoprotein and CFA, the number of Th17 and IFN-gamma-producing T cells are increased numbers in the central nervous system and detected earlier relative to in wild-type mice

abnormal interleukin level ( J:125296 )

• draining lymph nodes contain reduced levels of IL-4, IL-5 and IL-13

• however, the numbers of Foxp3+ regulatory T cells are normal

increased susceptibility to experimental autoimmune encephalomyelitis ( J:125296 )

• ollowing immunization with myelin oligodendrocyte glycoprotein and CFA, mice exhibit an earlier onset of experimental autoimmune encephalomyelitis (EAE), enhanced disease severity and all die by day 17 whereas wild-type mice survive

• 100% of mice develop EAE 6 days earlier than in wild-type mice

• following immunization with myelin oligodendrocyte glycoprotein and CFA, the number of Th17 and IFN-gamma-producing T cells are increased numbers in the central nervous system and detected earlier relative to in wild-type mice 2 days before the onset of EAE mice contain 55-fold more IL17+ T cells compared to wild-type mice

• at the peak of EAE mice contain more IL-17, IFN-gamma and TNF producing cells

• however, treatment with anti-IL17 antibodies inhibits EAE

hematopoietic system

increased T cell number ( J:125296 )

• following immunization with myelin oligodendrocyte glycoprotein and CFA, the number of Th17 and IFN-gamma-producing T cells are increased numbers in the central nervous system and detected earlier relative to in wild-type mice

homeostasis/metabolism

abnormal interleukin level ( J:125296 )

• draining lymph nodes contain reduced levels of IL-4, IL-5 and IL-13

• however, the numbers of Foxp3+ regulatory T cells are normal