Phenotypes associated with this allele

• Allele Symbol: Il25^tm1Anjm
• Allele Name: targeted mutation 1, Andrew N J McKenzie
• Allele ID: MGI:3720374
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il25^tm1Anjm/Il25^tm1Anjm	involves: 129P2/OlaHsd * C57BL/6	MGI:3721418

Genotype
MGI:3721418

hm1

• Allelic Composition: Il25^tm1Anjm/Il25^tm1Anjm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:123748 )

• after day 10 of N. brasiliensis infection, eosinophils are decreased in number relative to in wild-type mice

increased IgE level ( J:123748 )

• after day 10 of N. brasiliensis infection, IgE levels are elevated relative to in wild-type mice

abnormal mesenteric lymph node morphology ( J:123748 )

• after day 5 of N. brasiliensis infection, CD19-. CD4-. CD8- (non B non T), c-kit+, FcepsilonR1- cells are not increased in mesenteric lymph nodes as in wild-type mice

abnormal interleukin secretion ( J:123748 )

• after day 10 of N. brasiliensis infection, IL-4, IL-5 and IL-13 secretion is up-regulated but decreases at day 15 and day 20 when parasitic load is reduced

decreased interleukin-13 secretion ( J:123748 )

• following infection with N. brasiliensis, mice produce 5-fold less IL-5 and IL-13

decreased interleukin-5 secretion ( J:123748 )

• following infection with N. brasiliensis, mice produce 5-fold less IL-5 and IL-13

increased susceptibility to parasitic infection ( J:123748 )

• mice fail to expel N. brasiliensis by day 10 when wild-type mice have

hematopoietic system

decreased eosinophil cell number ( J:123748 )

• after day 10 of N. brasiliensis infection, eosinophils are decreased in number relative to in wild-type mice

increased IgE level ( J:123748 )

• after day 10 of N. brasiliensis infection, IgE levels are elevated relative to in wild-type mice