mortality/aging
• no homozygous progeny are derived from Esrrbtm1.2 heterozygous matings
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Allele Symbol Allele Name Allele ID |
Esrrbtm1.2Nat targeted mutation 1.2, Jeremy Nathans MGI:3720482 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no homozygous progeny are derived from Esrrbtm1.2 heterozygous matings
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no auditory startle reflex
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• observed beginning at several weeks of age
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• collapsed at 7 days of age
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• reduction in volume seen at 4 days of age
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• narrowing of membranous labyrinths of the three semicircular canals is observed in postnatal animals
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• flattening of ampullae is observed postnatally
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• loss of strial margenial cells in mutants is observed; this leads to loss of intraepithelial capillaries
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• ABR thresholds are variably elevated between 1 and 3 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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