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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myctm39Mnz
targeted mutation 39, Michel C Nussenzweig
MGI:3720515
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Myctm39Mnz/Myc+ involves: C57BL/6 MGI:3836390
cn2
 		Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm39Mnz/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3836396


Genotype
MGI:3836390
ht1
Allelic
Composition		 Myctm39Mnz/Myc+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm39Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• in activated B cells, Myc/Igh translocations involving chromosomes 12 and 15 occur 10-fold less frequently with the mutant Myc allele than with the wild-type allele




Genotype
MGI:3836396
cn2
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm39Mnz/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm39Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory