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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myctm37Mnz
targeted mutation 37, Michel C Nussenzweig
MGI:3720516
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Myctm37Mnz/Myc+ involves: C57BL/6 MGI:3836393
cn2
 		Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3836397
cx3
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: C57BL/6 * CBA MGI:3836398


Genotype
MGI:3836393
ht1
Allelic
Composition		 Myctm37Mnz/Myc+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:145691 )
• activated B cells transfected with yeast-derived I-SceI endonuclease have a 4-fold higher incidence of chromosomal translocations involving chromosomes 12 and 15 than do controls




Genotype
MGI:3836397
cn2
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles




Genotype
MGI:3836398
cx3
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:145691 )
• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15
• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles
• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions
• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory