About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myctm37Mnz
targeted mutation 37, Michel C Nussenzweig
MGI:3720516
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Myctm37Mnz/Myc+ involves: C57BL/6 MGI:3836393
cn2
 		Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3836397
cx3
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+ 		involves: C57BL/6 * CBA MGI:3836398


Genotype
MGI:3836393
ht1
Allelic
Composition		 Myctm37Mnz/Myc+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:145691 )
• activated B cells transfected with yeast-derived I-SceI endonuclease have a 4-fold higher incidence of chromosomal translocations involving chromosomes 12 and 15 than do controls




Genotype
MGI:3836397
cn2
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles




Genotype
MGI:3836398
cx3
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Igh+
Myctm37Mnz/Myc+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ightm3Mnz mutation (1 available); any Igh mutation (44 available)
Myctm37Mnz mutation (1 available); any Myc mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
induced chromosome breakage ( J:145691 )
• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15
• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles
• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions
• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory