All Phenotypes Aicda<tm1(cre)Mnz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aicda^tm1(cre)Mnz
targeted mutation 1, Michel C Nussenzweig
MGI:3720568

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aicda^tm1(cre)Mnz/Aicda⁺ Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4367198
cn2	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm39Mnz/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3836396
cn3	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3836397

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Gt(ROSA)26Sor^{tm2(sb11)Njen} mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased tumor incidence ( J:153656 )

• greater than 90% of moribund mice develop tumors with an average latency of 46 weeks

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

increased medulloblastoma incidence ( J:153656 )

• in one mouse

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including B cell, T cell, and myeloid tumors unlike Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice that do not develop tumors

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

increased leukemia incidence ( J:153656 )

• 2 myeloid leukemia tumors develop

increased B cell derived lymphoma incidence ( J:153656 )

• mice develop B cell lymphomas including diffuse large cell lymphomas and follicular lymphomas

• one mouse developed pre-B lymphoma

increased follicular lymphoma incidence ( J:153656 )

integument

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

nervous system

increased medulloblastoma incidence ( J:153656 )

• in one mouse

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

immune system

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

hematopoietic system

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm39Mnz/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (44 available)
Myc^tm39Mnz mutation (1 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (57 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (44 available)
Myc^tm37Mnz mutation (1 available); any Myc mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

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