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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4ratm2Tch
targeted mutation 2, Talal A Chatila
MGI:3720593
Summary 2 genotypes


Genotype
MGI:4361938
hm1
Allelic
Composition		 Il4ratm2Tch/Il4ratm2Tch
Genetic
Background		 C.129X1-Il4ratm2Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Tch mutation (1 available); any Il4ra mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lung histology staining of OVA-sensitized control (Q576) and Il4ratm2Tch/Il4ratm2Tch (R576) mice challenged intranasally with OVA on three consecutive days

respiratory system
respiratory system inflammation ( J:152376 )
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control
abnormal bronchus morphology ( J:152376 )
• OVA sensitized and challenged mutant (R576) mice exhibit patchy peribronchial inflammatory infiltrate that is more prominent that in Q576 controls
• peribronchial infiltrate is composed primarily of eosinophils and lymphoctyes
increased respiratory mucosa goblet cell number ( J:152376 )
• OVA or IL13 challenged mice exhibit goblet cell hyperplasia
increased airway responsiveness ( J:152376 )
• enhanced response to IL13 challenge

immune system
increased eosinophil cell number ( J:152376 )
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
increased monocyte cell number ( J:152376 )
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
increased IgE level ( J:152376 )
• following immunization with OVA or alum
abnormal T-helper 2 physiology ( J:152376 )
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13
increased circulating interleukin-4 level ( J:152376 )
• stimulated Th2 cells exhibit an increase in IL4 production
increased susceptibility to type I hypersensitivity reaction ( J:152376 )
• enhanced allergic inflammatory response following IL13 challenge
respiratory system inflammation ( J:152376 )
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control

hematopoietic system
increased eosinophil cell number ( J:152376 )
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
increased monocyte cell number ( J:152376 )
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
increased IgE level ( J:152376 )
• following immunization with OVA or alum
abnormal T-helper 2 physiology ( J:152376 )
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13

homeostasis/metabolism
increased circulating interleukin-4 level ( J:152376 )
• stimulated Th2 cells exhibit an increase in IL4 production

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
asthma DOID:2841 OMIM:600807
 J:152376




Genotype
MGI:4361939
cx2
Allelic
Composition		 Il4ratm2Tch/Il4ratm2Tch
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/?
Genetic
Background		 B6.Cg-Il4ratm2Tch Tg(Scgb1a1-rtTA,tetO-IL13)1Eli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Tch mutation (1 available); any Il4ra mutation (46 available)
Tg(Scgb1a1-rtTA,tetO-Il13)1Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system inflammation ( J:152376 )
• basal airway eosinophilia
increased respiratory mucosa goblet cell number ( J:152376 )
• percentage of goblet cells quadruples in mutant mice upon administration of doxycycline as compared to doubling in the control

immune system
increased eosinophil cell number ( J:152376 )
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference
respiratory system inflammation ( J:152376 )
• basal airway eosinophilia

hematopoietic system
increased eosinophil cell number ( J:152376 )
• basal airway eosinophilia is increased as compared to Q576 IL-13tg control
• administration of doxycycline amplifies difference




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory