Phenotypes associated with this allele

• Allele Symbol: Catsper4^tm1Wyan
• Allele Name: targeted mutation 1, Wei Yan
• Allele ID: MGI:3720685
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Catsper4^tm1Wyan/Catsper4^tm1Wyan	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3721373

Genotype
MGI:3721373

hm1

• Allelic Composition: Catsper4^tm1Wyan/Catsper4^tm1Wyan
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm motility ( J:124054 )

♂ • sperm motility decreases from 48% to 13% within 2 hours compared to wild-type sperm whose motility decreases from 67% to 51% within 2 hours

♂ • sperm fail to develop hyperactivated motility as do wild-type sperm

♂ • after 2 hours of incubation, sperm have reduced track velocity and path velocity compared to wild-type sperm that exhibit increased track velocity and path velocity and slightly reduced linear velocity

♂ • divalent-free (DVF)-activated whole current is undetectable

♂ • however, initial motility and spermatogenesis are normal

male infertility ( J:124054 )

♂ • males do not produce offspring

cellular

abnormal sperm motility ( J:124054 )

♂ • sperm motility decreases from 48% to 13% within 2 hours compared to wild-type sperm whose motility decreases from 67% to 51% within 2 hours

♂ • sperm fail to develop hyperactivated motility as do wild-type sperm

♂ • after 2 hours of incubation, sperm have reduced track velocity and path velocity compared to wild-type sperm that exhibit increased track velocity and path velocity and slightly reduced linear velocity

♂ • divalent-free (DVF)-activated whole current is undetectable

♂ • however, initial motility and spermatogenesis are normal