All Phenotypes Tg(Itgax-cre,-EGFP)4097Ach MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background	B6NTac.Cg-Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1^tm1.1Rds mutation (1 available); any Ifngr1 mutation (53 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

immune system

decreased interferon-gamma secretion ( J:206257 )

• from NK and NK T cells of mice infected with L. monocytogenes

• however, production in CD8+ T cells is normal

decreased interleukin-12b secretion ( J:206257 )

• reduced from CD8a+ dendritic cells of mice infected with L. monocytogenes

• production from Ly6c+ monocytes is temporarily delayed

increased susceptibility to bacterial infection ( J:206257 )

• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts, reduced IL12b production from CD8a+ dendritic cells compared with control mice

• intravenous L. monocytogenes infection results in reduced bacterial burden

• however, treatment with IL4 neutralizing antibody reduces bacterial burden

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

Allelic Composition	Cd1d1^tm1.1Aben/Cd1d1^tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background	C57BL/6-Cd1d1^tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm1.1Aben mutation (1 available); any Cd1d1 mutation (35 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:183087 )

N	• mice exhibit normal development and distribution of NK T cells

decreased interferon-gamma secretion ( J:183087 )

• decreased in splenic and liver NK T cells after injection of alphaGC

• absent in splenic and liver NK cells after injection of alphaGC

decreased interleukin-4 secretion ( J:183087 )

• decreased in splenic and liver NK T cells after injection of alphaGC

Allelic Composition	Abca1^tm1Jp/Abca1^tm1Jp Abcg1^tm1Tall/Abcg1^tm1Tall Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1^tm1Jp mutation (2 available); any Abca1 mutation (90 available)
Abcg1^tm1Tall mutation (1 available); any Abcg1 mutation (46 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:190966 )

• mice exhibit an increase in colony-forming units in the blood

immune system

increased interleukin-17 secretion ( J:190966 )

increased interleukin-23 secretion ( J:190966 )

• 1.8-fold in the spleen

Allelic Composition	Tlr5^tm1.1Gewr/Tlr5^tm1.1Gewr Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
Tlr5^tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total fat pad weight ( J:229155 )

digestive/alimentary system

abnormal gut flora balance ( J:229155 )

• delayed clearance of pathobiont bacteria

• decreased distance of fecal bacteria from intestinal epithelial cells

immune system

immune system phenotype ( J:229155 )

N	• mice do not exhibit spontaneous colitis, low grade inflammation or metabolic syndrome

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased dendritic cell number ( J:123556 )

• dendritic cell number increases with age in the spleen

abnormal spleen morphology ( J:123556 )

• mice exhibit histological changes in the spleen

• loss of follicular architecture is associated with splenomegaly

enlarged spleen ( J:123556 )

• splenomegaly is associated with loss of follicular architecture

abnormal spleen periarteriolar lymphoid sheath morphology ( J:123556 )

• dendritic cells are spread throughout the periarteriolar lymphoid sheath

increased immunoglobulin level ( J:123556 )

• mice have hyperimmunoglobulinemia

increased IgG level ( J:123556 )

increased IgM level ( J:123556 )

increased anti-nuclear antigen antibody level ( J:123556 )

• elevation in anti-nuclear antibodies occurs as early as 8 weeks in some mice and by 12 to 16 weeks in most mice

liver/biliary system

abnormal liver morphology ( J:123556 )

• mice exhibit histological changes in the liver

• polymorphic infiltrate, including Itgax+ dendritic cells and various

• leukocytes, is found around central veins in the liver

cellular

decreased apoptosis ( J:123556 )

• bone marrow dendritic cells are resistant to apoptosis following stimulation with LPS and exposure to CT26 carcinoma cells transfected with human FasL

• splenic dendritic cells are resistant to apoptosis in vivo initiated by cognate OT-1 T cells

hematopoietic system

increased dendritic cell number ( J:123556 )

• dendritic cell number increases with age in the spleen

abnormal spleen morphology ( J:123556 )

• mice exhibit histological changes in the spleen

• loss of follicular architecture is associated with splenomegaly

enlarged spleen ( J:123556 )

• splenomegaly is associated with loss of follicular architecture

abnormal spleen periarteriolar lymphoid sheath morphology ( J:123556 )

• dendritic cells are spread throughout the periarteriolar lymphoid sheath

increased immunoglobulin level ( J:123556 )

• mice have hyperimmunoglobulinemia

increased IgG level ( J:123556 )

increased IgM level ( J:123556 )

growth/size/body

enlarged spleen ( J:123556 )

• splenomegaly is associated with loss of follicular architecture

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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