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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Itgax-cre,-EGFP)4097Ach
transgene insertion 4097, Alexander V Chervonsky
MGI:3720729
Summary 5 genotypes


Genotype
MGI:5558060
cn1
Allelic
Composition		 Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background		 B6NTac.Cg-Ifngr1tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1tm1.1Rds mutation (1 available); any Ifngr1 mutation (53 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
decreased interferon-gamma secretion ( J:206257 )
• from NK and NK T cells of mice infected with L. monocytogenes
• however, production in CD8+ T cells is normal
decreased interleukin-12b secretion ( J:206257 )
• reduced from CD8a+ dendritic cells of mice infected with L. monocytogenes
• production from Ly6c+ monocytes is temporarily delayed
increased susceptibility to bacterial infection ( J:206257 )
• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts, reduced IL12b production from CD8a+ dendritic cells compared with control mice
• intravenous L. monocytogenes infection results in reduced bacterial burden
• however, treatment with IL4 neutralizing antibody reduces bacterial burden




Genotype
MGI:5318548
cn2
Allelic
Composition		 Cd1d1tm1.1Aben/Cd1d1tm1.1Aben
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background		 C57BL/6-Cd1d1tm1.1Aben Tg(Itgax-cre,-EGFP)4097Ach
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1.1Aben mutation (1 available); any Cd1d1 mutation (35 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:183087 )
N
• mice exhibit normal development and distribution of NK T cells
decreased interferon-gamma secretion ( J:183087 )
• decreased in splenic and liver NK T cells after injection of alphaGC
• absent in splenic and liver NK cells after injection of alphaGC
decreased interleukin-4 secretion ( J:183087 )
• decreased in splenic and liver NK T cells after injection of alphaGC




Genotype
MGI:5451018
cn3
Allelic
Composition		 Abca1tm1Jp/Abca1tm1Jp
Abcg1tm1Tall/Abcg1tm1Tall
Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca1tm1Jp mutation (2 available); any Abca1 mutation (90 available)
Abcg1tm1Tall mutation (1 available); any Abcg1 mutation (46 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell morphology/development ( J:190966 )
• mice exhibit an increase in colony-forming units in the blood

immune system
increased interleukin-23 secretion ( J:190966 )
• 1.8-fold in the spleen




Genotype
MGI:5751549
cn4
Allelic
Composition		 Tlr5tm1.1Gewr/Tlr5tm1.1Gewr
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background		 involves: C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
Tlr5tm1.1Gewr mutation (1 available); any Tlr5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue

digestive/alimentary system
abnormal gut flora balance ( J:229155 )
• delayed clearance of pathobiont bacteria
• decreased distance of fecal bacteria from intestinal epithelial cells

immune system
immune system phenotype ( J:229155 )
N
• mice do not exhibit spontaneous colitis, low grade inflammation or metabolic syndrome




Genotype
MGI:3720730
cn5
Allelic
Composition		 Fastm1Ach/Fastm1Ach
Tg(Itgax-cre,-EGFP)4097Ach/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased dendritic cell number ( J:123556 )
• dendritic cell number increases with age in the spleen
abnormal spleen morphology ( J:123556 )
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
enlarged spleen ( J:123556 )
• splenomegaly is associated with loss of follicular architecture
abnormal spleen periarteriolar lymphoid sheath morphology ( J:123556 )
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
increased immunoglobulin level ( J:123556 )
• mice have hyperimmunoglobulinemia
increased anti-nuclear antigen antibody level ( J:123556 )
• elevation in anti-nuclear antibodies occurs as early as 8 weeks in some mice and by 12 to 16 weeks in most mice

liver/biliary system
abnormal liver morphology ( J:123556 )
• mice exhibit histological changes in the liver
• polymorphic infiltrate, including Itgax+ dendritic cells and various
• leukocytes, is found around central veins in the liver

cellular
decreased apoptosis ( J:123556 )
• bone marrow dendritic cells are resistant to apoptosis following stimulation with LPS and exposure to CT26 carcinoma cells transfected with human FasL
• splenic dendritic cells are resistant to apoptosis in vivo initiated by cognate OT-1 T cells

hematopoietic system
increased dendritic cell number ( J:123556 )
• dendritic cell number increases with age in the spleen
abnormal spleen morphology ( J:123556 )
• mice exhibit histological changes in the spleen
• loss of follicular architecture is associated with splenomegaly
enlarged spleen ( J:123556 )
• splenomegaly is associated with loss of follicular architecture
abnormal spleen periarteriolar lymphoid sheath morphology ( J:123556 )
• dendritic cells are spread throughout the periarteriolar lymphoid sheath
increased immunoglobulin level ( J:123556 )
• mice have hyperimmunoglobulinemia

growth/size/body
enlarged spleen ( J:123556 )
• splenomegaly is associated with loss of follicular architecture




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory