Phenotypes associated with this allele

• Allele Symbol: Gab1^tm1Nmoc
• Allele Name: targeted mutation 1, Naoki Mochizuki
• Allele ID: MGI:3720732
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gab1^tm1Nmoc/Gab1^tm1Nmoc Gab2^tm1Thir/Gab2^tm1Thir Tg(Myh6-cre)2182Mds/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:3721269

Genotype
MGI:3721269

cn1

• Allelic Composition: Gab1^tm1Nmoc/Gab1^tm1Nmoc; Gab2^tm1Thir/Gab2^tm1Thir; Tg(Myh6-cre)2182Mds/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:124033 )

• 70% of mice die between 3 and 72 weeks due to heart failure

cardiovascular system

abnormal heart morphology ( J:124033 )

• sarcomere length in the heart is reduced

abnormal endocardium morphology ( J:124033 )

• after 3 weeks, deposits of elastic fibers and collagen in the endocardium are observed

thin interventricular septum ( J:124033 )

• at 10 weeks, the interventricular septal wall is thinned

increased heart weight ( J:124033 )

• mice have a higher heart weight-to-body weight ratio when compared to control mice

• both the left and right ventricle are enlarged

abnormal heart left ventricle morphology ( J:124033 )

• vessels in the left ventricle are abnormally dilated and are impaired in the recruitment of vascular smooth muscle cells

dilated heart ( J:124033 )

• mice that die of heart failure exhibit dilation of heart ventricles

decreased cardiac muscle contractility ( J:124033 )

• decrease in fractional shortening at 10 weeks of age

abnormal cardiac muscle relaxation ( J:124033 )

• left ventricle relaxation is impaired

increased left ventricle diastolic pressure ( J:124033 )

• at 10 weeks, the left ventricle end-diastolic dimension is increased and accompanied by decreased fractional shortening

congestive heart failure ( J:124033 )

• 70% of mice die between 3 and 72 weeks due to heart failure

muscle

decreased cardiac muscle contractility ( J:124033 )

• decrease in fractional shortening at 10 weeks of age

abnormal cardiac muscle relaxation ( J:124033 )

• left ventricle relaxation is impaired

growth/size/body

increased heart weight ( J:124033 )

• mice have a higher heart weight-to-body weight ratio when compared to control mice

• both the left and right ventricle are enlarged