Analysis Tools
mortality/aging
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• most pups die at E14.5
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• the few surviving mice are born and die shortly thereafter
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• 15% of pups die by E10.5
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nervous system
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• at E9.5, cell proliferation in the neural tube is increased ventrally
• at E10.5, cell proliferation is increased relative to in wild-type mice ventrally and dorsally
• there is a greater than 2-fold increase in the ratio of proliferating neural progenitors to differentiated cells in the neural tubethere is a greater than 2-fold increase in the ratio of proliferating neural progenitors to differentiated cells in the neural tube
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• at E9.25, pups possess neural tubes that have failed to close
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• in 15% of pups
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exencephaly
(
J:123924
)
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• 15% of pups exhibit severe exencephaly accompanied by a wavy neural tube and a shortened anterior to posterior axis
• after E10.5, surviving pups exhibit complete exencephaly from the forebrain to the hindbrainafter E10.5, surviving pups exhibit complete exencephaly from the forebrain to the hindbrain
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vision/eye
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• at E 12.5 and E14.5, proliferation in the retina is increased while differentiation in decreased
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• pups exhibit an outgrowth in the retinal epithelium
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• pups exhibit an outgrowth in the neural retina
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cellular
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• the cell cycle length is decreased and there are defects in entering and exiting the cell cycle
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embryo
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• 15% of pups are shortened in the anterior to posterior direction
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• at E9.5, cell proliferation in the neural tube is increased ventrally
• at E10.5, cell proliferation is increased relative to in wild-type mice ventrally and dorsally
• there is a greater than 2-fold increase in the ratio of proliferating neural progenitors to differentiated cells in the neural tubethere is a greater than 2-fold increase in the ratio of proliferating neural progenitors to differentiated cells in the neural tube
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• at E9.25, pups possess neural tubes that have failed to close
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• in 15% of pups
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pigmentation
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• pups exhibit an outgrowth in the retinal epithelium
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