behavior/neurological
• beginning at 15-20 months of age, mice show significantly diminished performance on the accelerating rotarod relative to nontransgenic controls; diminished ability is observed at 10-15 months of age, but does not reach significance
|
nervous system
• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age
|
muscle
• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle
• neutrophils are the predominant infiltrating cell type
|
• between 15-20 and 20-30 months of age, muscle fibers with centric nuclei are seen in transgenic mice
|
immune system
• between 10-15, 15-20, and 20-30 months of age, mice show cellular inflammation in transgenic muscle
• neutrophils are the predominant infiltrating cell type
|
homeostasis/metabolism
• between 10-15 months of age, mice show intracellular amyloid beta (Abeta) deposits in skeletal muscle; increase in mice with Abeta deposits in muscle is seen between 15-20 and 20-30 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
inclusion body myositis | DOID:3429 |
OMIM:147421 |
J:76338 |