About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atf7tm1Nicj
targeted mutation 1, Nic Jones
MGI:3720869
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atf7tm1Nicj/Atf7tm1Nicj B6.129P2-Atf7tm1Nicj MGI:3721131
cx2
Atf2tm1Nicj/Atf2tm1Nicj
Atf7tm1Nicj/Atf7tm1Nicj
involves: 129P2/OlaHsd * C57BL/6 MGI:3721133
cx3
Atf2tm2Nicj/Atf2tm2Nicj
Atf7tm1Nicj/Atf7tm1Nicj
involves: 129P2/OlaHsd * C57BL/6 MGI:3721134


Genotype
MGI:3721131
hm1
Allelic
Composition
Atf7tm1Nicj/Atf7tm1Nicj
Genetic
Background
B6.129P2-Atf7tm1Nicj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf7tm1Nicj mutation (0 available); any Atf7 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and have no gross abnormalities




Genotype
MGI:3721133
cx2
Allelic
Composition
Atf2tm1Nicj/Atf2tm1Nicj
Atf7tm1Nicj/Atf7tm1Nicj
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Nicj mutation (0 available); any Atf2 mutation (89 available)
Atf7tm1Nicj mutation (0 available); any Atf7 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

hematopoietic system
• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells
• some pups recovered between E11.5 and E12.5 are anemic

embryo
• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

growth/size/body
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation




Genotype
MGI:3721134
cx3
Allelic
Composition
Atf2tm2Nicj/Atf2tm2Nicj
Atf7tm1Nicj/Atf7tm1Nicj
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm2Nicj mutation (0 available); any Atf2 mutation (89 available)
Atf7tm1Nicj mutation (0 available); any Atf7 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

liver/biliary system
• at E11.5, a large increase in apoptotic liver cells is observed
• some pups recovered between E11.5 and E12.5 exhibit defects in liver architecture
• normal sized livers have severe tissue loss accompanied by expansion of sinuses
• a moderate decrease in proliferating liver cells and a large increase in apoptotic liver cells are observed even prior to reduction in liver size
• fewer erythropoeitic (Ter119+) cells are found due to increased apoptosis
• some pups recovered between E11.5 and E12.5 exhibit liver hypoplasia

hematopoietic system
• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells
• some pups recovered between E11.5 and E12.5 are anemic

cardiovascular system
• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages
• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages

embryo
• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

cellular
• hepatocytes and hematopoeitic cells of the liver undergo increased amounts of apoptosis
• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis
• at E11.5, a large increase in apoptotic liver cells is observed
• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis

growth/size/body
• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

homeostasis/metabolism
• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory