About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdk5tm1Bibb
targeted mutation 1, James A Bibb
MGI:3720892
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdk5tm1Bibb/Cdk5tm1Bibb
Tg(Prnp-cre/ERT)28.4Ics/0
involves: C57BL/6 * SJL MGI:3721114


Genotype
MGI:3721114
cn1
Allelic
Composition
Cdk5tm1Bibb/Cdk5tm1Bibb
Tg(Prnp-cre/ERT)28.4Ics/0
Genetic
Background
involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5tm1Bibb mutation (0 available); any Cdk5 mutation (17 available)
Tg(Prnp-cre/ERT)28.4Ics mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• synaptic plasticity is enhanced
• following treatment with tamoxifen, the ratio of NMDA/AMP excitatory postsynaptic currents (EPSCs) is increased 1.4+/-0.2-fold relative to in wild-type mice
• following treatment with tamoxifen, ifenprodil-sensitive EPSC charges are 3.2+/-0.5-fold more sensitive to ifenprodil and the decay time is longer compared to in wild-type mice
• following treatment with tamoxifen, field excitatory postsynaptic potential (fEPSP) is stimulated by low theta-burst stimulus that had no affect on wild-type mice
• following treatment with tamoxifen, NMDAR-mediated fEPSPs are increased relative to in wild-type mice and the ratio of NMDAR to AMPA fEPSP is 9.0+/-2.4-fold larger than in wild-type mice
• following treatment with tamoxifen, the induction threshold for long term potential is reduced but is reversed with ifenprodil treatment
• following treatment with tamoxifen, a stronger theta-burst that elicits a long term potential in wild-type mice elevates post-tetanic potential in mice compared to wild-type mice

behavior/neurological
• following treatment with tamoxifen, mice exhibit increased freezing when re-exposed to context at 24 hours
• following treatment with tamoxifen, less freezing is observed on the fourth exposure at 96 hours after training compared to wild-type mice
• following treatment with tamoxifen, when platform position in a water maze is reversed, mice exhibit shortened escape latency
• following treatment with tamoxifen, mice show improved performance in a reversal special learning task





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory